Oxidative Stress and Its Association with COVID-19: A Narrative Review
The naturalness of severe acute respiratory syndrome coronavirus 2 infections (SARS-Cov-2) appears to impact the respiratory system and lungs, however, the etiology of many cases exhibited several various features of the disease. The Coronavirus disease 2019 (COVID-19) symptoms are not limited to th...
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| Format: | Article |
| Language: | English |
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Sulaimani Polytechnic University
2020-06-01
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| Series: | Kurdistan Journal of Applied Research |
| Subjects: | |
| Online Access: | https://kjar.spu.edu.iq/index.php/kjar/article/view/516 |
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| _version_ | 1823861326393376768 |
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| author | Hardi Rafat Baqi Halgord Ali M. Farag Abdel Hamid H. El Bilbeisi Rafee Habib Askandar Amany M. El Afifi |
| author_facet | Hardi Rafat Baqi Halgord Ali M. Farag Abdel Hamid H. El Bilbeisi Rafee Habib Askandar Amany M. El Afifi |
| author_sort | Hardi Rafat Baqi |
| collection | DOAJ |
| description | The naturalness of severe acute respiratory syndrome coronavirus 2 infections (SARS-Cov-2) appears to impact the respiratory system and lungs, however, the etiology of many cases exhibited several various features of the disease. The Coronavirus disease 2019 (COVID-19) symptoms are not limited to the virus’s first definitions. This review gathered the contemporary information throughout PubMed, Scopus, and Science Direct databases regarding possible effects of the virus in generating reactive oxygen species and causing oxidative stress. However, this ensures a hypothesis for now, yet from the literature and incidence of COVID-19 symptoms along with comorbidities we can observe the potentials of the virus in the generation of oxidative stress. Especially the virus’s route to cell entry via angiotensin-converting enzyme 2 (ACE2) receptor is well known that leads to pathogenesis in angiotensin II (AT II) which are critical in NADH/NADPH oxidase inducing ROS generation. Moreover, the virus’s activity to replicate seems to be reduced in high antioxidant glutathione level concentrations. The outcome of the review proposes a hypothesis that COVID-19 is associated with reactive oxygen species and its comorbidities mostly joined with oxidative stress including hypertension, cardiovascular, thrombosis, obesity, and diabetes besides of chronic obstructive pulmonary disease and asthma.
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| format | Article |
| id | doaj-art-3d2e3f52b0f04717abf85127be40b29f |
| institution | Kabale University |
| issn | 2411-7684 2411-7706 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Sulaimani Polytechnic University |
| record_format | Article |
| series | Kurdistan Journal of Applied Research |
| spelling | doaj-art-3d2e3f52b0f04717abf85127be40b29f2025-02-09T21:00:15ZengSulaimani Polytechnic UniversityKurdistan Journal of Applied Research2411-76842411-77062020-06-015310.24017/covid.11Oxidative Stress and Its Association with COVID-19: A Narrative ReviewHardi Rafat Baqi0https://orcid.org/0000-0002-1134-1076Halgord Ali M. Farag1Abdel Hamid H. El Bilbeisi2Rafee Habib Askandar3Amany M. El Afifi4Medical Laboratory Science, Technical College of Applied Sciences | Research Center, Sulaimani Polytechnic University, Sulaimani, IraqNursing department, Technical College of Health | Research Center, Sulaimani Polytechnic University, Sulaimani, IraqClinical Nutrition Department , Faculty of Pharmacy, Al Azhar University of Gaza, Gaza, PalestineNursing department, Technical College of Health | Research Center, Sulaimani Polytechnic University, Sulaimani, IraqClinical Pharmacy Department Faculty of Pharmacy Al Azhar University of Gaza Gaza, PalestineThe naturalness of severe acute respiratory syndrome coronavirus 2 infections (SARS-Cov-2) appears to impact the respiratory system and lungs, however, the etiology of many cases exhibited several various features of the disease. The Coronavirus disease 2019 (COVID-19) symptoms are not limited to the virus’s first definitions. This review gathered the contemporary information throughout PubMed, Scopus, and Science Direct databases regarding possible effects of the virus in generating reactive oxygen species and causing oxidative stress. However, this ensures a hypothesis for now, yet from the literature and incidence of COVID-19 symptoms along with comorbidities we can observe the potentials of the virus in the generation of oxidative stress. Especially the virus’s route to cell entry via angiotensin-converting enzyme 2 (ACE2) receptor is well known that leads to pathogenesis in angiotensin II (AT II) which are critical in NADH/NADPH oxidase inducing ROS generation. Moreover, the virus’s activity to replicate seems to be reduced in high antioxidant glutathione level concentrations. The outcome of the review proposes a hypothesis that COVID-19 is associated with reactive oxygen species and its comorbidities mostly joined with oxidative stress including hypertension, cardiovascular, thrombosis, obesity, and diabetes besides of chronic obstructive pulmonary disease and asthma. https://kjar.spu.edu.iq/index.php/kjar/article/view/516ACE2COVID-19Oxidative stressROSSARS-CoV-2 |
| spellingShingle | Hardi Rafat Baqi Halgord Ali M. Farag Abdel Hamid H. El Bilbeisi Rafee Habib Askandar Amany M. El Afifi Oxidative Stress and Its Association with COVID-19: A Narrative Review Kurdistan Journal of Applied Research ACE2 COVID-19 Oxidative stress ROS SARS-CoV-2 |
| title | Oxidative Stress and Its Association with COVID-19: A Narrative Review |
| title_full | Oxidative Stress and Its Association with COVID-19: A Narrative Review |
| title_fullStr | Oxidative Stress and Its Association with COVID-19: A Narrative Review |
| title_full_unstemmed | Oxidative Stress and Its Association with COVID-19: A Narrative Review |
| title_short | Oxidative Stress and Its Association with COVID-19: A Narrative Review |
| title_sort | oxidative stress and its association with covid 19 a narrative review |
| topic | ACE2 COVID-19 Oxidative stress ROS SARS-CoV-2 |
| url | https://kjar.spu.edu.iq/index.php/kjar/article/view/516 |
| work_keys_str_mv | AT hardirafatbaqi oxidativestressanditsassociationwithcovid19anarrativereview AT halgordalimfarag oxidativestressanditsassociationwithcovid19anarrativereview AT abdelhamidhelbilbeisi oxidativestressanditsassociationwithcovid19anarrativereview AT rafeehabibaskandar oxidativestressanditsassociationwithcovid19anarrativereview AT amanymelafifi oxidativestressanditsassociationwithcovid19anarrativereview |