Comparing effectiveness of adding prolonged trimetazidine or isosorbide dinitrate to beta-adrenoblocker therapy in stable angina patients
Aim. To study effects of adding isosorbide dinitrate (ID) and trimetazidine MB 35 mg (Tr) to beta-adrenoblocker therapy in stable angina (SA) patients. Material and methods. In total, 40 patients with Functional Class II-III SA were examined. Combined therapy effectiveness was studied in a three-mon...
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«SILICEA-POLIGRAF» LLC
2006-08-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1229 |
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| author | M. G. Glezer M. V. Novikova I. V. Kiseleva R. T. Saigitov |
| author_facet | M. G. Glezer M. V. Novikova I. V. Kiseleva R. T. Saigitov |
| author_sort | M. G. Glezer |
| collection | DOAJ |
| description | Aim. To study effects of adding isosorbide dinitrate (ID) and trimetazidine MB 35 mg (Tr) to beta-adrenoblocker therapy in stable angina (SA) patients. Material and methods. In total, 40 patients with Functional Class II-III SA were examined. Combined therapy effectiveness was studied in a three-month randomized, open, comparative, parallel trial. Physical stress tolerance (PST) in treadmill test, angina attack incidence, nitrate dose, and health self-assessment dynamics (visual analogue scale) were assessed. Results. In both groups, PST increase by Month 1 was similar: 17% and 19%, respectively. Then PST stayed the same in ID group, and further increased in Tr group. By Month 3, PST in Tr group was twice as high as that in ID group: 15% and 34%, respectively. In Tr group, ST depression reduction, comparing to the baseline, was greater than in ID group: 49% vs 27%, respectively. It was associated with reduced angina attack incidence and need in short-acting nitrates. General health self-assessment improved by 20% (Month 1) and 35% (Month 3), comparing to 13% and 18% in ID group, respectively. Two participants dropped out of ID group, due to low medication tolerability (n=2), and myocardial infarction development (n=1). Conclusion. Comparing to ID, Tr demonstrated better tolerability profile, and long-run tolerance effect absence. |
| format | Article |
| id | doaj-art-3d284dc1a92d4a618ae687300b7bca45 |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2006-08-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-3d284dc1a92d4a618ae687300b7bca452025-08-20T03:57:17Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252006-08-01545764940Comparing effectiveness of adding prolonged trimetazidine or isosorbide dinitrate to beta-adrenoblocker therapy in stable angina patientsM. G. Glezer0M. V. Novikova1I. V. Kiseleva2R. T. Saigitov3I.M. Sechenov Moscow Medical Academy, City Clinical Hospital No. 59. MoscowI.M. Sechenov Moscow Medical Academy, City Clinical Hospital No. 59. MoscowI.M. Sechenov Moscow Medical Academy, City Clinical Hospital No. 59. MoscowI.M. Sechenov Moscow Medical Academy, City Clinical Hospital No. 59. MoscowAim. To study effects of adding isosorbide dinitrate (ID) and trimetazidine MB 35 mg (Tr) to beta-adrenoblocker therapy in stable angina (SA) patients. Material and methods. In total, 40 patients with Functional Class II-III SA were examined. Combined therapy effectiveness was studied in a three-month randomized, open, comparative, parallel trial. Physical stress tolerance (PST) in treadmill test, angina attack incidence, nitrate dose, and health self-assessment dynamics (visual analogue scale) were assessed. Results. In both groups, PST increase by Month 1 was similar: 17% and 19%, respectively. Then PST stayed the same in ID group, and further increased in Tr group. By Month 3, PST in Tr group was twice as high as that in ID group: 15% and 34%, respectively. In Tr group, ST depression reduction, comparing to the baseline, was greater than in ID group: 49% vs 27%, respectively. It was associated with reduced angina attack incidence and need in short-acting nitrates. General health self-assessment improved by 20% (Month 1) and 35% (Month 3), comparing to 13% and 18% in ID group, respectively. Two participants dropped out of ID group, due to low medication tolerability (n=2), and myocardial infarction development (n=1). Conclusion. Comparing to ID, Tr demonstrated better tolerability profile, and long-run tolerance effect absence.https://cardiovascular.elpub.ru/jour/article/view/1229stable anginatrimetazidineisosorbide dinitratephysical stress tolerancetreadmill |
| spellingShingle | M. G. Glezer M. V. Novikova I. V. Kiseleva R. T. Saigitov Comparing effectiveness of adding prolonged trimetazidine or isosorbide dinitrate to beta-adrenoblocker therapy in stable angina patients Кардиоваскулярная терапия и профилактика stable angina trimetazidine isosorbide dinitrate physical stress tolerance treadmill |
| title | Comparing effectiveness of adding prolonged trimetazidine or isosorbide dinitrate to beta-adrenoblocker therapy in stable angina patients |
| title_full | Comparing effectiveness of adding prolonged trimetazidine or isosorbide dinitrate to beta-adrenoblocker therapy in stable angina patients |
| title_fullStr | Comparing effectiveness of adding prolonged trimetazidine or isosorbide dinitrate to beta-adrenoblocker therapy in stable angina patients |
| title_full_unstemmed | Comparing effectiveness of adding prolonged trimetazidine or isosorbide dinitrate to beta-adrenoblocker therapy in stable angina patients |
| title_short | Comparing effectiveness of adding prolonged trimetazidine or isosorbide dinitrate to beta-adrenoblocker therapy in stable angina patients |
| title_sort | comparing effectiveness of adding prolonged trimetazidine or isosorbide dinitrate to beta adrenoblocker therapy in stable angina patients |
| topic | stable angina trimetazidine isosorbide dinitrate physical stress tolerance treadmill |
| url | https://cardiovascular.elpub.ru/jour/article/view/1229 |
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