Natural Mineral Water–Plant Extract Combinations as Potential Anti-Aging Ingredients: An <i>In Vitro</i> Evaluation
Natural mineral waters (NMWs) and plant extracts have long been valued for their therapeutic properties and skin benefits. This study investigated, in vitro, the role of five Portuguese NMWs (A-E), combined with plant extracts from five species (<i>Ficus carica</i> L., <i>Rubus ida...
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MDPI AG
2025-05-01
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| Series: | Cosmetics |
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| Online Access: | https://www.mdpi.com/2079-9284/12/3/113 |
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| author | Carolina P. Gomes Ana S. Oliveira Joana Rolo Tayse F. F. da Silveira Rita Palmeira de Oliveira Maria José Alves Paula Plasencia Ana Palmeira de Oliveira |
| author_facet | Carolina P. Gomes Ana S. Oliveira Joana Rolo Tayse F. F. da Silveira Rita Palmeira de Oliveira Maria José Alves Paula Plasencia Ana Palmeira de Oliveira |
| author_sort | Carolina P. Gomes |
| collection | DOAJ |
| description | Natural mineral waters (NMWs) and plant extracts have long been valued for their therapeutic properties and skin benefits. This study investigated, in vitro, the role of five Portuguese NMWs (A-E), combined with plant extracts from five species (<i>Ficus carica</i> L., <i>Rubus idaeus</i> L., <i>Vaccinium myrtillus</i>, <i>Cistus ladanifer</i> and <i>Thymus</i> x <i>citriodorus</i>) as bioactive ingredients. Antioxidant capacity was assessed using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) method. Cellular biocompatibility was evaluated in fibroblasts (L929) and macrophages (RAW 264.7). Skin-repairing and anti-senescence properties were evaluated in L929 cells through the scratch-wound method and β-galactosidase assay. Superoxide dismutase (SOD) was quantified using a commercial kit, and lipopolysaccharide-induced reactive oxygen species (ROS) were quantified using a fluorescent probe (H<sub>2</sub>DCFDA) in RAW 264.7. The results highlighted the beneficial impact of extracts combined with NMWs. An increase in antioxidant capacity of up to 90% was observed in mixtures comprising <i>Ficus carica</i> L., compared with NMWs alone. In contrast, mixtures with <i>Cistus ladanifer</i> showed promising anti-aging potential, with a 40% decrease in senescent cells and a 33% ROS reduction. <i>Rubus idaeus</i> L. extract produced an increase in cell migration capacity (up to 50%), depending on the NMW. This study highlights the potential synergism of natural ingredients with plant extracts for anti-aging. |
| format | Article |
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| institution | Kabale University |
| issn | 2079-9284 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Cosmetics |
| spelling | doaj-art-3d23a3c23c2b4fa2a043f1fd6eedcb392025-08-20T03:24:39ZengMDPI AGCosmetics2079-92842025-05-0112311310.3390/cosmetics12030113Natural Mineral Water–Plant Extract Combinations as Potential Anti-Aging Ingredients: An <i>In Vitro</i> EvaluationCarolina P. Gomes0Ana S. Oliveira1Joana Rolo2Tayse F. F. da Silveira3Rita Palmeira de Oliveira4Maria José Alves5Paula Plasencia6Ana Palmeira de Oliveira7RISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, PortugalRISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, PortugalRISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, PortugalCIMO, LA SusTEC, Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, PortugalRISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, PortugalCIMO, LA SusTEC, Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, PortugalCIMO, LA SusTEC, Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, PortugalRISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, PortugalNatural mineral waters (NMWs) and plant extracts have long been valued for their therapeutic properties and skin benefits. This study investigated, in vitro, the role of five Portuguese NMWs (A-E), combined with plant extracts from five species (<i>Ficus carica</i> L., <i>Rubus idaeus</i> L., <i>Vaccinium myrtillus</i>, <i>Cistus ladanifer</i> and <i>Thymus</i> x <i>citriodorus</i>) as bioactive ingredients. Antioxidant capacity was assessed using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) method. Cellular biocompatibility was evaluated in fibroblasts (L929) and macrophages (RAW 264.7). Skin-repairing and anti-senescence properties were evaluated in L929 cells through the scratch-wound method and β-galactosidase assay. Superoxide dismutase (SOD) was quantified using a commercial kit, and lipopolysaccharide-induced reactive oxygen species (ROS) were quantified using a fluorescent probe (H<sub>2</sub>DCFDA) in RAW 264.7. The results highlighted the beneficial impact of extracts combined with NMWs. An increase in antioxidant capacity of up to 90% was observed in mixtures comprising <i>Ficus carica</i> L., compared with NMWs alone. In contrast, mixtures with <i>Cistus ladanifer</i> showed promising anti-aging potential, with a 40% decrease in senescent cells and a 33% ROS reduction. <i>Rubus idaeus</i> L. extract produced an increase in cell migration capacity (up to 50%), depending on the NMW. This study highlights the potential synergism of natural ingredients with plant extracts for anti-aging.https://www.mdpi.com/2079-9284/12/3/113anti-agingagro-industrial residueshydrolatesnatural mineral watersskincare |
| spellingShingle | Carolina P. Gomes Ana S. Oliveira Joana Rolo Tayse F. F. da Silveira Rita Palmeira de Oliveira Maria José Alves Paula Plasencia Ana Palmeira de Oliveira Natural Mineral Water–Plant Extract Combinations as Potential Anti-Aging Ingredients: An <i>In Vitro</i> Evaluation Cosmetics anti-aging agro-industrial residues hydrolates natural mineral waters skincare |
| title | Natural Mineral Water–Plant Extract Combinations as Potential Anti-Aging Ingredients: An <i>In Vitro</i> Evaluation |
| title_full | Natural Mineral Water–Plant Extract Combinations as Potential Anti-Aging Ingredients: An <i>In Vitro</i> Evaluation |
| title_fullStr | Natural Mineral Water–Plant Extract Combinations as Potential Anti-Aging Ingredients: An <i>In Vitro</i> Evaluation |
| title_full_unstemmed | Natural Mineral Water–Plant Extract Combinations as Potential Anti-Aging Ingredients: An <i>In Vitro</i> Evaluation |
| title_short | Natural Mineral Water–Plant Extract Combinations as Potential Anti-Aging Ingredients: An <i>In Vitro</i> Evaluation |
| title_sort | natural mineral water plant extract combinations as potential anti aging ingredients an i in vitro i evaluation |
| topic | anti-aging agro-industrial residues hydrolates natural mineral waters skincare |
| url | https://www.mdpi.com/2079-9284/12/3/113 |
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