TERT promoter mutations in thyroid cancer
TERT promoter mutations (TERT-p mutations) have been found in many types of cancer and have emerged to play critical roles in tumor progression. The mutations upregulate TERT transcription, and TERT not only elongates telomeres and confers unlimited proliferative capacity on tumor cells, but is also...
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| Language: | English |
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The Japan Endocrine Society
2023-11-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/70/11/70_EJ23-0136/_html/-char/en |
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| _version_ | 1832591691628937216 |
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| author | Michiko Matsuse Norisato Mitsutake |
| author_facet | Michiko Matsuse Norisato Mitsutake |
| author_sort | Michiko Matsuse |
| collection | DOAJ |
| description | TERT promoter mutations (TERT-p mutations) have been found in many types of cancer and have emerged to play critical roles in tumor progression. The mutations upregulate TERT transcription, and TERT not only elongates telomeres and confers unlimited proliferative capacity on tumor cells, but is also involved in tumor progression and aggressiveness. In differentiated thyroid carcinoma, TERT-p mutations are associated with a number of high-risk clinicopathological aggressiveness and worse prognosis, making it the best molecular marker to predict tumor aggressiveness so far. This review summarizes recent relevant findings regarding TERT-p mutations and their functional/mechanistic aspects. |
| format | Article |
| id | doaj-art-3d1d60a7c28941d19f207257e6d5fdbd |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-3d1d60a7c28941d19f207257e6d5fdbd2025-01-22T06:23:18ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402023-11-0170111035104910.1507/endocrj.EJ23-0136endocrjTERT promoter mutations in thyroid cancerMichiko Matsuse0Norisato Mitsutake1Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523, JapanDepartment of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523, JapanTERT promoter mutations (TERT-p mutations) have been found in many types of cancer and have emerged to play critical roles in tumor progression. The mutations upregulate TERT transcription, and TERT not only elongates telomeres and confers unlimited proliferative capacity on tumor cells, but is also involved in tumor progression and aggressiveness. In differentiated thyroid carcinoma, TERT-p mutations are associated with a number of high-risk clinicopathological aggressiveness and worse prognosis, making it the best molecular marker to predict tumor aggressiveness so far. This review summarizes recent relevant findings regarding TERT-p mutations and their functional/mechanistic aspects.https://www.jstage.jst.go.jp/article/endocrj/70/11/70_EJ23-0136/_html/-char/enthyroid cancertelomerase reverse transcriptase (tert)promotermutation |
| spellingShingle | Michiko Matsuse Norisato Mitsutake TERT promoter mutations in thyroid cancer Endocrine Journal thyroid cancer telomerase reverse transcriptase (tert) promoter mutation |
| title | TERT promoter mutations in thyroid cancer |
| title_full | TERT promoter mutations in thyroid cancer |
| title_fullStr | TERT promoter mutations in thyroid cancer |
| title_full_unstemmed | TERT promoter mutations in thyroid cancer |
| title_short | TERT promoter mutations in thyroid cancer |
| title_sort | tert promoter mutations in thyroid cancer |
| topic | thyroid cancer telomerase reverse transcriptase (tert) promoter mutation |
| url | https://www.jstage.jst.go.jp/article/endocrj/70/11/70_EJ23-0136/_html/-char/en |
| work_keys_str_mv | AT michikomatsuse tertpromotermutationsinthyroidcancer AT norisatomitsutake tertpromotermutationsinthyroidcancer |