<i>Candida albicans</i> Induces Oral Microbial Dysbiosis and Promotes Oral Diseases
<i>Candida albicans</i> are ubiquitous fungal organisms that colonize the oral cavity of healthy individuals without causing disease. <i>C. albicans</i> is an opportunistic microorganism with several virulent factors that influence the inflammatory process and allow it to inv...
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MDPI AG
2024-10-01
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| author | Bina Kashyap Sridhar Reddy Padala Gaganjot Kaur Arja Kullaa |
| author_facet | Bina Kashyap Sridhar Reddy Padala Gaganjot Kaur Arja Kullaa |
| author_sort | Bina Kashyap |
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| description | <i>Candida albicans</i> are ubiquitous fungal organisms that colonize the oral cavity of healthy individuals without causing disease. <i>C. albicans</i> is an opportunistic microorganism with several virulent factors that influence the inflammatory process and allow it to invade tissues, evade host defense mechanisms, and release toxins, facilitating proliferation and degradation. At present, increasing emphasis is placed on polymicrobial interactions between <i>C. albicans</i> and various bacterial pathogens. Such interaction is mutually beneficial for both parties: it is competitive and antagonistic. Their complex interaction and colonization in the oral cavity serve as the basis for several oral diseases. The dispersion of <i>C. albicans</i> in saliva and the systemic circulation is noted in association with other bacterial populations, suggesting their virulence in causing disease. Hence, it is necessary to understand fungal–bacterial interactions for early detection and the development of novel therapeutic strategies to treat oral diseases. In this paper, we review the mutualistic interaction of <i>C. albicans</i> in oral biofilm formation and polymicrobial interactions in oral diseases. In addition, <i>C. albicans</i> virulence in causing biofilm-related oral diseases and its presence in saliva are discussed. |
| format | Article |
| id | doaj-art-3d1ce665fe314ec190f94fcad2fa709f |
| institution | OA Journals |
| issn | 2076-2607 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
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| series | Microorganisms |
| spelling | doaj-art-3d1ce665fe314ec190f94fcad2fa709f2025-08-20T02:05:06ZengMDPI AGMicroorganisms2076-26072024-10-011211213810.3390/microorganisms12112138<i>Candida albicans</i> Induces Oral Microbial Dysbiosis and Promotes Oral DiseasesBina Kashyap0Sridhar Reddy Padala1Gaganjot Kaur2Arja Kullaa3Institute of Dentistry, University of Eastern Finland, 70211 Kuopio, FinlandAgartala Government Dental College, West Tripura, Agartala 799001, IndiaShaheed Kartar Singh Sarabha Dental College & Hospital, Ludhiana 141105, IndiaInstitute of Dentistry, University of Eastern Finland, 70211 Kuopio, Finland<i>Candida albicans</i> are ubiquitous fungal organisms that colonize the oral cavity of healthy individuals without causing disease. <i>C. albicans</i> is an opportunistic microorganism with several virulent factors that influence the inflammatory process and allow it to invade tissues, evade host defense mechanisms, and release toxins, facilitating proliferation and degradation. At present, increasing emphasis is placed on polymicrobial interactions between <i>C. albicans</i> and various bacterial pathogens. Such interaction is mutually beneficial for both parties: it is competitive and antagonistic. Their complex interaction and colonization in the oral cavity serve as the basis for several oral diseases. The dispersion of <i>C. albicans</i> in saliva and the systemic circulation is noted in association with other bacterial populations, suggesting their virulence in causing disease. Hence, it is necessary to understand fungal–bacterial interactions for early detection and the development of novel therapeutic strategies to treat oral diseases. In this paper, we review the mutualistic interaction of <i>C. albicans</i> in oral biofilm formation and polymicrobial interactions in oral diseases. In addition, <i>C. albicans</i> virulence in causing biofilm-related oral diseases and its presence in saliva are discussed.https://www.mdpi.com/2076-2607/12/11/2138Candidamicroorganismoral microbiotadysbiosisoral diseases |
| spellingShingle | Bina Kashyap Sridhar Reddy Padala Gaganjot Kaur Arja Kullaa <i>Candida albicans</i> Induces Oral Microbial Dysbiosis and Promotes Oral Diseases Microorganisms Candida microorganism oral microbiota dysbiosis oral diseases |
| title | <i>Candida albicans</i> Induces Oral Microbial Dysbiosis and Promotes Oral Diseases |
| title_full | <i>Candida albicans</i> Induces Oral Microbial Dysbiosis and Promotes Oral Diseases |
| title_fullStr | <i>Candida albicans</i> Induces Oral Microbial Dysbiosis and Promotes Oral Diseases |
| title_full_unstemmed | <i>Candida albicans</i> Induces Oral Microbial Dysbiosis and Promotes Oral Diseases |
| title_short | <i>Candida albicans</i> Induces Oral Microbial Dysbiosis and Promotes Oral Diseases |
| title_sort | i candida albicans i induces oral microbial dysbiosis and promotes oral diseases |
| topic | Candida microorganism oral microbiota dysbiosis oral diseases |
| url | https://www.mdpi.com/2076-2607/12/11/2138 |
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