Metabolic perturbation of epigenome by inhibiting -adenosylhomocysteine hydrolase elicits senescence through DNA damage response in hepatoma cells

Metabolic perturbation of epigenome by inhibiting -adenosylhomocysteine hydrolase elicits senescence through DNA damage response in hepatoma cells

Cellular senescence is a key physiological barrier against tumor and represents an option for therapeutic intervention. One pivotal intracellular stimulus causing senescence is DNA damage response, while the senescence-associated heterochromatin in cancer limits the strength of the DNA damage respon...

Full description

Saved in:
Bibliographic Details
Main Authors: Guozhen Wu, Ning Wang, Ying Luo, Yanyan Zhang, Peng Wang, Zhengyan Zhu, Yingtang Gao, Zhi Du, Bin Yang
Format: Article
Language:English
Published: SAGE Publishing 2017-04-01
Series:Tumor Biology
Online Access:https://doi.org/10.1177/1010428317699117
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items