Migraine and traumatic brain injury: a cohort study in Taiwan
Objective Traumatic brain injury is now a major contributor to the global healthcare burden. Migraine is another debilitating disease with a global health impact. While most researchers agree that traumatic brain injury is a risk factor for migraine, whether migraine is a risk factor for traumatic b...
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| Format: | Article |
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BMJ Publishing Group
2019-07-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/7/e027251.full |
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| author | Li Zhang Qing-Rui Wang Ying-Yi Lu Ying-Ju Su Hao Qin Ming-Kung Wu Cong-Liang Zhang Chieh-Hsin Wu |
| author_facet | Li Zhang Qing-Rui Wang Ying-Yi Lu Ying-Ju Su Hao Qin Ming-Kung Wu Cong-Liang Zhang Chieh-Hsin Wu |
| author_sort | Li Zhang |
| collection | DOAJ |
| description | Objective Traumatic brain injury is now a major contributor to the global healthcare burden. Migraine is another debilitating disease with a global health impact. While most researchers agree that traumatic brain injury is a risk factor for migraine, whether migraine is a risk factor for traumatic brain injury still remains under debate. We therefore aimed to investigate whether migraine was a risk factor for developing traumatic brain injury.Study design Retrospective population-based cohort study.Setting Data for people who had been diagnosed with migraine were retrieved from Taiwan’s National Health Insurance Research Database.Participants We identified 7267 patients with newly diagnosed migraine during 1996–2010. The migraineurs to non-migraineurs ratio was set at 1:4 to enhance the power of statistical tests.Primary and secondary outcome measures We used multivariate Cox proportional hazard regression models to assess the effects of migraines on the risk of traumatic brain injury after adjusting for potential confounders.Results The overall traumatic brain injury risk was 1.78 times greater in the migraine group compared with the non-migraine group after controlling for covariates. Additionally, patients with previous diagnoses of alcohol-attributed disease, mental disorders and diabetes mellitus had a significantly higher traumatic brain injury risk compared with those with no history of these diagnoses.Conclusions This study of a population-based database indicated that migraine is a traumatic brain injury risk factor. Greater attention to migraine-targeted treatment modalities may reduce traumatic brain injury-related morbidity and mortality. |
| format | Article |
| id | doaj-art-3d0e96940fb24772a9a4e9202a7d63d0 |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-3d0e96940fb24772a9a4e9202a7d63d02025-08-20T02:49:04ZengBMJ Publishing GroupBMJ Open2044-60552019-07-019710.1136/bmjopen-2018-027251Migraine and traumatic brain injury: a cohort study in TaiwanLi Zhang0Qing-Rui Wang1Ying-Yi Lu2Ying-Ju Su3Hao Qin4Ming-Kung Wu5Cong-Liang Zhang6Chieh-Hsin Wu7School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Respiratory Health and Multimorbidity, Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College), Ministry of Education, Beijing, China4 Department of Neurosurgery, Qinghe County Central Hospital of Hebei Province, Qinghe, Hebei, P.R. China4 Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan5 Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan6 Department of Neurosurgery, Zaozhuang Municipal Hospital, Zaozhuang, Shandong, China14 Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan7 Department of Cardiology, Hebei Quyang Renji Hospital, Quyang, Hebei, P.R. China10 Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanObjective Traumatic brain injury is now a major contributor to the global healthcare burden. Migraine is another debilitating disease with a global health impact. While most researchers agree that traumatic brain injury is a risk factor for migraine, whether migraine is a risk factor for traumatic brain injury still remains under debate. We therefore aimed to investigate whether migraine was a risk factor for developing traumatic brain injury.Study design Retrospective population-based cohort study.Setting Data for people who had been diagnosed with migraine were retrieved from Taiwan’s National Health Insurance Research Database.Participants We identified 7267 patients with newly diagnosed migraine during 1996–2010. The migraineurs to non-migraineurs ratio was set at 1:4 to enhance the power of statistical tests.Primary and secondary outcome measures We used multivariate Cox proportional hazard regression models to assess the effects of migraines on the risk of traumatic brain injury after adjusting for potential confounders.Results The overall traumatic brain injury risk was 1.78 times greater in the migraine group compared with the non-migraine group after controlling for covariates. Additionally, patients with previous diagnoses of alcohol-attributed disease, mental disorders and diabetes mellitus had a significantly higher traumatic brain injury risk compared with those with no history of these diagnoses.Conclusions This study of a population-based database indicated that migraine is a traumatic brain injury risk factor. Greater attention to migraine-targeted treatment modalities may reduce traumatic brain injury-related morbidity and mortality.https://bmjopen.bmj.com/content/9/7/e027251.full |
| spellingShingle | Li Zhang Qing-Rui Wang Ying-Yi Lu Ying-Ju Su Hao Qin Ming-Kung Wu Cong-Liang Zhang Chieh-Hsin Wu Migraine and traumatic brain injury: a cohort study in Taiwan BMJ Open |
| title | Migraine and traumatic brain injury: a cohort study in Taiwan |
| title_full | Migraine and traumatic brain injury: a cohort study in Taiwan |
| title_fullStr | Migraine and traumatic brain injury: a cohort study in Taiwan |
| title_full_unstemmed | Migraine and traumatic brain injury: a cohort study in Taiwan |
| title_short | Migraine and traumatic brain injury: a cohort study in Taiwan |
| title_sort | migraine and traumatic brain injury a cohort study in taiwan |
| url | https://bmjopen.bmj.com/content/9/7/e027251.full |
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