Brucella secretory protein VceA promotes FOXO1 entry into the nucleus to shift host cell metabolism toward glycolysis

Brucella secretory protein VceA promotes FOXO1 entry into the nucleus to shift host cell metabolism toward glycolysis

Increased glycolytic metabolism is a key step in the reproduction of Brucella and the induction of brucellosis, however, little is known about how this process is regulated during infection. Forkhead box protein O1 (FOXO1) is a transcription factor that regulates energy metabolism. In this study, we...

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Bibliographic Details
Main Authors: Cao Shuzhu, Han Xinxin, Deng Xingmei, Guo Jia, Liu Liangbo, Zhang Yu, Suleimenov Maratbek, Zhao Tianyi, Li Wei, Ding Jian, Xie Songsong, Zhang Hui
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2024-11-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
<italic>Brucella abortus</italic>
VceA
FOXO1
glycolysis
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2024203
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