Caenorhabditis elegans in the biological activity research of tea: From “little transparent” to “big star”
Caenorhabditis elegans (C. elegans) has proven to be a valuable model organism for assessing active ingredients. The wide array of active compounds found in tea, including tea polyphenols, amino acids, alkaloids, and aromatic substances, has provided numerous health benefits. In C. elegans, active i...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000155 |
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| author | Lingwei Yang Zhonghua Liu Ligui Xiong Yushun Gong |
| author_facet | Lingwei Yang Zhonghua Liu Ligui Xiong Yushun Gong |
| author_sort | Lingwei Yang |
| collection | DOAJ |
| description | Caenorhabditis elegans (C. elegans) has proven to be a valuable model organism for assessing active ingredients. The wide array of active compounds found in tea, including tea polyphenols, amino acids, alkaloids, and aromatic substances, has provided numerous health benefits. In C. elegans, active ingredients such as catechins and their derivatives, L-theanine, and caffeine have exhibited various biological effects, including slowing down aging, enhancing environmental adaptations, regulating protein homeostasis and glycolipid metabolism, and participating in immunomodulation. The worms play a crucial role in studying the mechanisms of tea polyphenols and exploring the bioactivity of catechin derivatives. Here, we discuss how these active ingredients promote worms' health, and elucidate their mechanisms of action. We further offer recommendations for utilizing nematodes and microorganisms as host-microbe models to combine multiple active tea components in the diet or to investigate the unique chemical components present in other teas, aiming to enhance our understanding of the health benefits of tea consumption on biological organisms. |
| format | Article |
| id | doaj-art-3d0dcb4e11d64274bf3e8bcc40f7ce13 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-3d0dcb4e11d64274bf3e8bcc40f7ce132025-02-09T04:59:55ZengElsevierJournal of Functional Foods1756-46462025-02-01125106673Caenorhabditis elegans in the biological activity research of tea: From “little transparent” to “big star”Lingwei Yang0Zhonghua Liu1Ligui Xiong2Yushun Gong3Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, Hunan 410128, ChinaKey Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, Hunan 410128, China; National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha, Hunan 410128, China; Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha, Hunan 410128, China; Key Laboratory for Evaluation and Utilization of Gene Resources of Horticultural Crops, Ministry of Agriculture and Rural Affairs of China, Hunan Agricultural University, Changsha, Hunan 410128, China; Corresponding authors at: Key Laboratory of Tea Science of Ministry of Education, Changsha, 410128, China.Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, Hunan 410128, China; Corresponding authors at: Key Laboratory of Tea Science of Ministry of Education, Changsha, 410128, China.Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, Hunan 410128, China; Yuelushan Laboratory, Changsha, Hunan 410128, China; Corresponding authors at: Key Laboratory of Tea Science of Ministry of Education, Changsha, 410128, China.Caenorhabditis elegans (C. elegans) has proven to be a valuable model organism for assessing active ingredients. The wide array of active compounds found in tea, including tea polyphenols, amino acids, alkaloids, and aromatic substances, has provided numerous health benefits. In C. elegans, active ingredients such as catechins and their derivatives, L-theanine, and caffeine have exhibited various biological effects, including slowing down aging, enhancing environmental adaptations, regulating protein homeostasis and glycolipid metabolism, and participating in immunomodulation. The worms play a crucial role in studying the mechanisms of tea polyphenols and exploring the bioactivity of catechin derivatives. Here, we discuss how these active ingredients promote worms' health, and elucidate their mechanisms of action. We further offer recommendations for utilizing nematodes and microorganisms as host-microbe models to combine multiple active tea components in the diet or to investigate the unique chemical components present in other teas, aiming to enhance our understanding of the health benefits of tea consumption on biological organisms.http://www.sciencedirect.com/science/article/pii/S1756464625000155TeaC. elegansHealth benefitsPolyphenols |
| spellingShingle | Lingwei Yang Zhonghua Liu Ligui Xiong Yushun Gong Caenorhabditis elegans in the biological activity research of tea: From “little transparent” to “big star” Journal of Functional Foods Tea C. elegans Health benefits Polyphenols |
| title | Caenorhabditis elegans in the biological activity research of tea: From “little transparent” to “big star” |
| title_full | Caenorhabditis elegans in the biological activity research of tea: From “little transparent” to “big star” |
| title_fullStr | Caenorhabditis elegans in the biological activity research of tea: From “little transparent” to “big star” |
| title_full_unstemmed | Caenorhabditis elegans in the biological activity research of tea: From “little transparent” to “big star” |
| title_short | Caenorhabditis elegans in the biological activity research of tea: From “little transparent” to “big star” |
| title_sort | caenorhabditis elegans in the biological activity research of tea from little transparent to big star |
| topic | Tea C. elegans Health benefits Polyphenols |
| url | http://www.sciencedirect.com/science/article/pii/S1756464625000155 |
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