Impact of a prenatal screening program on the Down syndrome phenotype: An interrupted time series analysis

Abstract Introduction We hypothesized that children with Down syndrome who were born after the implementation of first‐trimester combined screening for trisomy 13, 18, and 21 and a second‐trimester ultrasound scan in Denmark would show a milder syndrome phenotype. We investigated the birth biometry,...

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Bibliographic Details
Main Authors: Ellen Hollands Steffensen, Lars Henning Pedersen, Stina Lou, Ida Vogel, The Danish Cytogenetic Central Registry Study Group
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:Acta Obstetricia et Gynecologica Scandinavica
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Online Access:https://doi.org/10.1111/aogs.14573
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