Reassessing the validity of using weighted linear models to implement multi-generational GWAS-by-subtraction: a response to Evans et al.
Abstract Evans and colleagues for providing a critique on our article “Deriving GWAS summary estimates for paternal smoking in UK biobank: a GWAS by subtraction”. They highlight important limitations in our approach, which we overlooked. They argue that our approach works neither in theory nor in pr...
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| Format: | Article |
| Language: | English |
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BMC
2025-06-01
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| Series: | BMC Research Notes |
| Online Access: | https://doi.org/10.1186/s13104-025-07327-8 |
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| author | Benjamin Woolf Dipender Gill Marcus Munafò Stephen Burgess |
| author_facet | Benjamin Woolf Dipender Gill Marcus Munafò Stephen Burgess |
| author_sort | Benjamin Woolf |
| collection | DOAJ |
| description | Abstract Evans and colleagues for providing a critique on our article “Deriving GWAS summary estimates for paternal smoking in UK biobank: a GWAS by subtraction”. They highlight important limitations in our approach, which we overlooked. They argue that our approach works neither in theory nor in practice– that there are both flaws in the method and in our execution of the method. Here we explore these issues and address what we consider to be the most important criticisms. |
| format | Article |
| id | doaj-art-3d05102eb41d42e1b741d55a6f0213aa |
| institution | OA Journals |
| issn | 1756-0500 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj-art-3d05102eb41d42e1b741d55a6f0213aa2025-08-20T02:35:39ZengBMCBMC Research Notes1756-05002025-06-011811510.1186/s13104-025-07327-8Reassessing the validity of using weighted linear models to implement multi-generational GWAS-by-subtraction: a response to Evans et al.Benjamin Woolf0Dipender Gill1Marcus Munafò2Stephen Burgess3MRC Integrative Epidemiology Unit, University of BristolDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College LondonMRC Integrative Epidemiology Unit, University of BristolMRC Biostatistics Unit, University of CambridgeAbstract Evans and colleagues for providing a critique on our article “Deriving GWAS summary estimates for paternal smoking in UK biobank: a GWAS by subtraction”. They highlight important limitations in our approach, which we overlooked. They argue that our approach works neither in theory nor in practice– that there are both flaws in the method and in our execution of the method. Here we explore these issues and address what we consider to be the most important criticisms.https://doi.org/10.1186/s13104-025-07327-8 |
| spellingShingle | Benjamin Woolf Dipender Gill Marcus Munafò Stephen Burgess Reassessing the validity of using weighted linear models to implement multi-generational GWAS-by-subtraction: a response to Evans et al. BMC Research Notes |
| title | Reassessing the validity of using weighted linear models to implement multi-generational GWAS-by-subtraction: a response to Evans et al. |
| title_full | Reassessing the validity of using weighted linear models to implement multi-generational GWAS-by-subtraction: a response to Evans et al. |
| title_fullStr | Reassessing the validity of using weighted linear models to implement multi-generational GWAS-by-subtraction: a response to Evans et al. |
| title_full_unstemmed | Reassessing the validity of using weighted linear models to implement multi-generational GWAS-by-subtraction: a response to Evans et al. |
| title_short | Reassessing the validity of using weighted linear models to implement multi-generational GWAS-by-subtraction: a response to Evans et al. |
| title_sort | reassessing the validity of using weighted linear models to implement multi generational gwas by subtraction a response to evans et al |
| url | https://doi.org/10.1186/s13104-025-07327-8 |
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