Evidence of the neuroprotective potential of NeuroEPO in preclinical studies and clinical trials; A systematic review
Introduction: Neuroprotection is an essential purpose in the treatment of neurological disorders and several investigations have evaluated the usefulness of NeuroEPO in preclinical studies and clinical trials. Objective: To evaluate the neuroprotective potential of NeuroEPO in neurological disorders...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universidad de Ciencias Médicas de La Habana
2023-12-01
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| Series: | Revista Habanera de Ciencias Médicas |
| Subjects: | |
| Online Access: | https://revhabanera.sld.cu/index.php/rhab/article/view/5452 |
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| Summary: | Introduction: Neuroprotection is an essential purpose in the
treatment of neurological disorders and several investigations have
evaluated the usefulness of NeuroEPO in preclinical studies and clinical
trials.
Objective: To evaluate the neuroprotective potential of NeuroEPO
in neurological disorders.
Material and Methods: A systematic review of original articles in
Spanish and English was conducted using PRISMA methodology, guided
by the question: Is NeuroEPO a safe and effective therapeutic candidate
for neuroprotection in neurological disorders? LILACS and PubMed
databases, and Google Scholar search engine were used.
Results: With the strategy followed, a total of 20 articles were
included for synthesis and review. Preclinical studies were conducted
in biomodels of cerebral ischemia and Alzheimer's disease, while
clinical trials were conducted in patients with neurodegenerative
diseases. Safety, tolerability, and efficacy of NeuroEPO were found
when administered intranasally with varying doses, frequency of
administration, and duration of intervention. Neuroprotective effects
were observed in all studies, and some molecular mechanisms
mediating these effects were evidenced.
Conclusions: NeuroEPO has been reported to be a safe product,
without hematopoietic effects, and well tolerated intranasally, which
provides benefits in conditions of ischemic or degenerative brain
damage by stimulating endogenous neuroprotection mechanisms with
antioxidant, anti-inflammatory, and antiapoptotic action. The results
support the continuity of studies aimed at enriching the scientific
evidence of the potential of NeuroEPO for the treatment of neurological
disorders |
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| ISSN: | 1729-519X |