Serum Levels of Il-8, Tnf-α And Il-6 in Children with Atopic Dermatitis
Introduction: Atopic dermatitis (AD) is associated with an imbalance between T helper 1 (Th1) and T helper 2 (Th2) cells. It is chronic relapsing inflammatory skin disease affecting especially the children. Recently, it has been intensively studied and new aspects regarding the immunopathogenesi...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2012-08-01
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| Series: | Güncel Pediatri |
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| Online Access: | http://www.guncelpediatri.com/eng/makale/3201/102/Full-Text |
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| author | Perihan Öztürk Murat Aral Ergül Belge Kurutaş Ekrem Kireççi Mustafa Çelik |
| author_facet | Perihan Öztürk Murat Aral Ergül Belge Kurutaş Ekrem Kireççi Mustafa Çelik |
| author_sort | Perihan Öztürk |
| collection | DOAJ |
| description | Introduction: Atopic dermatitis (AD) is associated with an imbalance between T helper 1 (Th1) and T helper 2 (Th2) cells. It is chronic relapsing inflammatory skin disease affecting especially the children. Recently, it has been intensively studied and new aspects regarding the immunopathogenesis are suggested. Studies about the role of cytokines on formation of atopic diseases are rather new and most of them are based on in vitro observations. It is not completely clear yet how cytokines regulate diseases in vivo and studies about this subject are rather limited. In this study; the serum levels of IL-8, TNF-α, IL-6 and the relationship between these parameters and the disease severity in a group of children with AD were investigated.Materials and Methods: The severity of AD was assessed by the same dermatologist using the Scoring Atopic Dermatitis (SCORAD) index system. IL-8, TNF-α, and IL-6 levels were measured by ELISA method.Results: Serum levels of IL-8, TNF-α and IL-6 were determined and were found statistically significantly higher in patients than controls. A statistically significant correlation between serum levels of IL-8, TNF-α, and IL-6 and SCORADs in children with AD was determined.Conclusion: These results show that serum levels of IL-8, TNF-α, and IL-6 may be used as important markers in the assessment of disease severity and follow-up of child patients with AD. As a result, the role of cytokines and the relationship between cytokines in the immunopathogenesis of AD are rather complex and still not clearly clarified, further investigations are required to understand this complex process. (Journal of Current Pediatrics 2012; 10: 50-4) |
| format | Article |
| id | doaj-art-3d00536ba23b4fe9a27f74ca5ddf109b |
| institution | Kabale University |
| issn | 1304-9054 |
| language | English |
| publishDate | 2012-08-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Güncel Pediatri |
| spelling | doaj-art-3d00536ba23b4fe9a27f74ca5ddf109b2025-01-02T03:27:55ZengGalenos Publishing HouseGüncel Pediatri1304-90542012-08-011025054Serum Levels of Il-8, Tnf-α And Il-6 in Children with Atopic DermatitisPerihan ÖztürkMurat AralErgül Belge KurutaşEkrem KireççiMustafa ÇelikIntroduction: Atopic dermatitis (AD) is associated with an imbalance between T helper 1 (Th1) and T helper 2 (Th2) cells. It is chronic relapsing inflammatory skin disease affecting especially the children. Recently, it has been intensively studied and new aspects regarding the immunopathogenesis are suggested. Studies about the role of cytokines on formation of atopic diseases are rather new and most of them are based on in vitro observations. It is not completely clear yet how cytokines regulate diseases in vivo and studies about this subject are rather limited. In this study; the serum levels of IL-8, TNF-α, IL-6 and the relationship between these parameters and the disease severity in a group of children with AD were investigated.Materials and Methods: The severity of AD was assessed by the same dermatologist using the Scoring Atopic Dermatitis (SCORAD) index system. IL-8, TNF-α, and IL-6 levels were measured by ELISA method.Results: Serum levels of IL-8, TNF-α and IL-6 were determined and were found statistically significantly higher in patients than controls. A statistically significant correlation between serum levels of IL-8, TNF-α, and IL-6 and SCORADs in children with AD was determined.Conclusion: These results show that serum levels of IL-8, TNF-α, and IL-6 may be used as important markers in the assessment of disease severity and follow-up of child patients with AD. As a result, the role of cytokines and the relationship between cytokines in the immunopathogenesis of AD are rather complex and still not clearly clarified, further investigations are required to understand this complex process. (Journal of Current Pediatrics 2012; 10: 50-4)http://www.guncelpediatri.com/eng/makale/3201/102/Full-TextAtopic dermatitisIL-8TNF- αIL-6disease severity |
| spellingShingle | Perihan Öztürk Murat Aral Ergül Belge Kurutaş Ekrem Kireççi Mustafa Çelik Serum Levels of Il-8, Tnf-α And Il-6 in Children with Atopic Dermatitis Güncel Pediatri Atopic dermatitis IL-8 TNF- α IL-6 disease severity |
| title | Serum Levels of Il-8, Tnf-α And Il-6 in Children with Atopic Dermatitis |
| title_full | Serum Levels of Il-8, Tnf-α And Il-6 in Children with Atopic Dermatitis |
| title_fullStr | Serum Levels of Il-8, Tnf-α And Il-6 in Children with Atopic Dermatitis |
| title_full_unstemmed | Serum Levels of Il-8, Tnf-α And Il-6 in Children with Atopic Dermatitis |
| title_short | Serum Levels of Il-8, Tnf-α And Il-6 in Children with Atopic Dermatitis |
| title_sort | serum levels of il 8 tnf α and il 6 in children with atopic dermatitis |
| topic | Atopic dermatitis IL-8 TNF- α IL-6 disease severity |
| url | http://www.guncelpediatri.com/eng/makale/3201/102/Full-Text |
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