Distinct germ-line genetic mutation patterns correlate with reproductive outcomes in ICSI patients: a pilot study

Distinct germ-line genetic mutation patterns correlate with reproductive outcomes in ICSI patients: a pilot study

BackgroundInfertility affects approximately 15% of couples worldwide, with male factors accounting for nearly 50% of cases. Intracytoplasmic sperm injection (ICSI) has become the standard treatment for male factor infertility, but outcomes vary significantly among couples. While conventional genetic...

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Bibliographic Details
Main Authors: Ting Jiang, Yan Wang, Wandai Wu, Qianru Yang, Sixian Wu, Xueguang Zhang, Wenming Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Genetics
Subjects:
sperm whole-exome sequencing
ICSI outcomes
genetic variants
fertilization failure
implantation failure
pregnancy loss
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1610943/full
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