Estimation of TNF- α and some immunological parameters in patient with systemic lupus erythematosus
Abstract: Abstract— Systemic Lupus Erythematosus (SLE) is a multifactorial chronic systemic autoimmune disease. It is characterized by a lack of immune tolerance to autoantigens such as nuclear antigens. In this study, 25 individuals diagnosed with SLE had their blood samples drawn, while 25 healt...
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University of Thi-Qar
2024-12-01
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| Series: | مجلة علوم ذي قار |
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| Online Access: | https://jsci.utq.edu.iq/index.php/main/article/view/1197 |
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| author | sarah AL-abdullah Murtada Hafedh Hussein |
| author_facet | sarah AL-abdullah Murtada Hafedh Hussein |
| author_sort | sarah AL-abdullah |
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Abstract:
Abstract— Systemic Lupus Erythematosus (SLE) is a multifactorial chronic systemic autoimmune disease. It is characterized by a lack of immune tolerance to autoantigens such as nuclear antigens. In this study, 25 individuals diagnosed with SLE had their blood samples drawn, while 25 healthy individuals were used as a control group. The results of this investigation show that the patients' TNF-α levels (106.9 ± 10.8) significantly increased more than 52.86 in the control group. Comparing the immunological parameters of the patients to the healthy group, the study revealed a decrease in the eosinophile, basophile, lymphocyte, and monocyte counts (010 ± 0.003, 0.022 ± 0.004, 1.71 ± 0.66, 0.21 ± 0.047 respectively) and a rise in the neutrophile and immature granulocyte counts (7.43 ± 1.66, 2.68 ± 0.46 respectively) in SLE patient.
Keywords— SLE,TNF‑α,immunological parameters
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| format | Article |
| id | doaj-art-3cf999e0e65d44e3978c5300fe32ce2e |
| institution | Kabale University |
| issn | 1991-8690 2709-0256 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | University of Thi-Qar |
| record_format | Article |
| series | مجلة علوم ذي قار |
| spelling | doaj-art-3cf999e0e65d44e3978c5300fe32ce2e2024-12-31T20:45:27ZengUniversity of Thi-Qarمجلة علوم ذي قار1991-86902709-02562024-12-0111210.32792/utq/utjsci/v11i2.1197Estimation of TNF- α and some immunological parameters in patient with systemic lupus erythematosussarah AL-abdullah0Murtada Hafedh Hussein1Dept. of Pathological Analysis College of Science / University of Thi-Qar Thi-Qar / IraqDept. of Pathological Analysis, College of Science, University of Thi-Qar, Abstract: Abstract— Systemic Lupus Erythematosus (SLE) is a multifactorial chronic systemic autoimmune disease. It is characterized by a lack of immune tolerance to autoantigens such as nuclear antigens. In this study, 25 individuals diagnosed with SLE had their blood samples drawn, while 25 healthy individuals were used as a control group. The results of this investigation show that the patients' TNF-α levels (106.9 ± 10.8) significantly increased more than 52.86 in the control group. Comparing the immunological parameters of the patients to the healthy group, the study revealed a decrease in the eosinophile, basophile, lymphocyte, and monocyte counts (010 ± 0.003, 0.022 ± 0.004, 1.71 ± 0.66, 0.21 ± 0.047 respectively) and a rise in the neutrophile and immature granulocyte counts (7.43 ± 1.66, 2.68 ± 0.46 respectively) in SLE patient. Keywords— SLE,TNF‑α,immunological parameters https://jsci.utq.edu.iq/index.php/main/article/view/1197SLE,TNF α,immunological parameters |
| spellingShingle | sarah AL-abdullah Murtada Hafedh Hussein Estimation of TNF- α and some immunological parameters in patient with systemic lupus erythematosus مجلة علوم ذي قار SLE,TNF α,immunological parameters |
| title | Estimation of TNF- α and some immunological parameters in patient with systemic lupus erythematosus |
| title_full | Estimation of TNF- α and some immunological parameters in patient with systemic lupus erythematosus |
| title_fullStr | Estimation of TNF- α and some immunological parameters in patient with systemic lupus erythematosus |
| title_full_unstemmed | Estimation of TNF- α and some immunological parameters in patient with systemic lupus erythematosus |
| title_short | Estimation of TNF- α and some immunological parameters in patient with systemic lupus erythematosus |
| title_sort | estimation of tnf α and some immunological parameters in patient with systemic lupus erythematosus |
| topic | SLE,TNF α,immunological parameters |
| url | https://jsci.utq.edu.iq/index.php/main/article/view/1197 |
| work_keys_str_mv | AT sarahalabdullah estimationoftnfaandsomeimmunologicalparametersinpatientwithsystemiclupuserythematosus AT murtadahafedhhussein estimationoftnfaandsomeimmunologicalparametersinpatientwithsystemiclupuserythematosus |