Safety and immunogenicity of a recombinant double-mutant heat-labile toxin derived from enterotoxigenic Escherichia coli in healthy Bangladeshi adults delivered by three different routes

Safety and immunogenicity of a recombinant double-mutant heat-labile toxin derived from enterotoxigenic Escherichia coli in healthy Bangladeshi adults delivered by three different routes

IntroductionEnterotoxigenic Escherichia coli (ETEC) is a common cause of acute watery diarrhea in areas lacking access to clean water, sanitation, and hygiene. This Phase 1 trial measured the safety and immunogenicity of double-mutant heat-labile enterotoxin (dmLT) of ETEC in healthy adults in Bangl...

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Main Authors: Taufiqur Rahman Bhuiyan, Farhana Khanam, Salima Raiyan Basher, Pinki Dash, Mohiul Islam Chowdhury, Shahinur Haque, Nabila Binte Harun, Aklima Akter, Polash Chandra Karmakar, Al Hakim, Shaheena Amin, Mohammad Kamruzzaman, Nasrin Parvin, Tasnuva Ahmed, Jessica Butts, Marcela F. Pasetti, Rezwanul Wahid, Marcelo B. Sztein, Nicole Maier, Jessica A. White, Kay M. Tomashek, A. Louis Bourgeois, Shahida Baqar, Karen L. Kotloff, Firdausi Qadri, Wilbur H. Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Bacteriology
Subjects:
enterotoxigenic Escherichia coli
diarrhea
vaccine
adjuvant
double-mutant heat-labile toxin
Online Access:https://www.frontiersin.org/articles/10.3389/fbrio.2025.1567791/full
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