The Common Hallmarks and Interconnected Pathways of Aging, Circadian Rhythms, and Cancer: Implications for Therapeutic Strategies
The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis and cancer progression. Aging is a well-established primary risk factor for cancer, while disruptions in circadian rhythms...
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2025-01-01
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| Series: | Research |
| Online Access: | https://spj.science.org/doi/10.34133/research.0612 |
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| author | Jie Wang Fanglin Shao Qing Xin Yu Luxia Ye Dilinaer Wusiman Ruicheng Wu Zhouting Tuo Zhipeng Wang Dengxiong Li William C. Cho Wuran Wei Dechao Feng |
| author_facet | Jie Wang Fanglin Shao Qing Xin Yu Luxia Ye Dilinaer Wusiman Ruicheng Wu Zhouting Tuo Zhipeng Wang Dengxiong Li William C. Cho Wuran Wei Dechao Feng |
| author_sort | Jie Wang |
| collection | DOAJ |
| description | The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis and cancer progression. Aging is a well-established primary risk factor for cancer, while disruptions in circadian rhythms are intricately associated with the tumorigenesis and progression of various tumors. Moreover, aging itself disrupts circadian rhythms, leading to physiological changes that may accelerate cancer development. Despite these connections, the specific interplay between these processes and their collective impact on cancer remains inadequately explored in the literature. In this review, we systematically explore the physiological mechanisms of circadian rhythms and their influence on cancer development. We discuss how core circadian genes impact tumor risk and prognosis, highlighting the shared hallmarks of cancer and aging such as genomic instability, cellular senescence, and chronic inflammation. Furthermore, we examine the interplay between circadian rhythms and aging, focusing on how this crosstalk contributes to tumorigenesis, tumor proliferation, and apoptosis, as well as the impact on cellular metabolism and genomic stability. By elucidating the common pathways linking aging, circadian rhythms, and cancer, this review provides new insights into the pathophysiology of cancer and identifies potential therapeutic strategies. We propose that targeting the circadian regulation of cancer hallmarks could pave the way for novel treatments, including chronotherapy and antiaging interventions, which may offer important benefits in the clinical management of cancer. |
| format | Article |
| id | doaj-art-3cf5decf60114beb97e6acf22595e408 |
| institution | DOAJ |
| issn | 2639-5274 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Research |
| spelling | doaj-art-3cf5decf60114beb97e6acf22595e4082025-08-20T03:12:20ZengAmerican Association for the Advancement of Science (AAAS)Research2639-52742025-01-01810.34133/research.0612The Common Hallmarks and Interconnected Pathways of Aging, Circadian Rhythms, and Cancer: Implications for Therapeutic StrategiesJie Wang0Fanglin Shao1Qing Xin Yu2Luxia Ye3Dilinaer Wusiman4Ruicheng Wu5Zhouting Tuo6Zhipeng Wang7Dengxiong Li8William C. Cho9Wuran Wei10Dechao Feng11Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.Department of Pathology, Ningbo Clinical Pathology Diagnosis Center, Ningbo, Zhejiang 315211, China.Department of Public Research Platform, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.Department of Urological Surgery, Daping Hospital, Army Medical Center of PLA, Army Medical University, Chongqing, China.Department of Urology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China.Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR, China.Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis and cancer progression. Aging is a well-established primary risk factor for cancer, while disruptions in circadian rhythms are intricately associated with the tumorigenesis and progression of various tumors. Moreover, aging itself disrupts circadian rhythms, leading to physiological changes that may accelerate cancer development. Despite these connections, the specific interplay between these processes and their collective impact on cancer remains inadequately explored in the literature. In this review, we systematically explore the physiological mechanisms of circadian rhythms and their influence on cancer development. We discuss how core circadian genes impact tumor risk and prognosis, highlighting the shared hallmarks of cancer and aging such as genomic instability, cellular senescence, and chronic inflammation. Furthermore, we examine the interplay between circadian rhythms and aging, focusing on how this crosstalk contributes to tumorigenesis, tumor proliferation, and apoptosis, as well as the impact on cellular metabolism and genomic stability. By elucidating the common pathways linking aging, circadian rhythms, and cancer, this review provides new insights into the pathophysiology of cancer and identifies potential therapeutic strategies. We propose that targeting the circadian regulation of cancer hallmarks could pave the way for novel treatments, including chronotherapy and antiaging interventions, which may offer important benefits in the clinical management of cancer.https://spj.science.org/doi/10.34133/research.0612 |
| spellingShingle | Jie Wang Fanglin Shao Qing Xin Yu Luxia Ye Dilinaer Wusiman Ruicheng Wu Zhouting Tuo Zhipeng Wang Dengxiong Li William C. Cho Wuran Wei Dechao Feng The Common Hallmarks and Interconnected Pathways of Aging, Circadian Rhythms, and Cancer: Implications for Therapeutic Strategies Research |
| title | The Common Hallmarks and Interconnected Pathways of Aging, Circadian Rhythms, and Cancer: Implications for Therapeutic Strategies |
| title_full | The Common Hallmarks and Interconnected Pathways of Aging, Circadian Rhythms, and Cancer: Implications for Therapeutic Strategies |
| title_fullStr | The Common Hallmarks and Interconnected Pathways of Aging, Circadian Rhythms, and Cancer: Implications for Therapeutic Strategies |
| title_full_unstemmed | The Common Hallmarks and Interconnected Pathways of Aging, Circadian Rhythms, and Cancer: Implications for Therapeutic Strategies |
| title_short | The Common Hallmarks and Interconnected Pathways of Aging, Circadian Rhythms, and Cancer: Implications for Therapeutic Strategies |
| title_sort | common hallmarks and interconnected pathways of aging circadian rhythms and cancer implications for therapeutic strategies |
| url | https://spj.science.org/doi/10.34133/research.0612 |
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