High-altitude hypoxia exacerbates chemotherapy-induced myelosuppression by lowering serum G-CSF/GM-CSF and regulating apoptosis and proliferation

High-altitude hypoxia exacerbates chemotherapy-induced myelosuppression by lowering serum G-CSF/GM-CSF and regulating apoptosis and proliferation

Abstract The unique hypoxic environment in high-altitude regions is increasingly drawing attention for its impact on the health of residents, particularly in patients post-chemotherapy. This study aimed to investigate the effects and potential mechanisms of high-altitude hypoxia on myelosuppression...

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Bibliographic Details
Main Authors: Jing Shi, Fuxing Zhao, Tianlei Qiu, Dengfeng Ren, Zitao Li, Junli Ma, Jiuda Zhao
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Discover Oncology
Subjects:
High-altitude hypoxia
Chemotherapy
Myelosuppression
Hematopoietic function
Online Access:https://doi.org/10.1007/s12672-025-02611-2
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