Current application of tissue-engineered dermal scaffolds mimicking the extracellular matrix microenvironment in wound healing
With the continuous advancement of materials science, cell biology, and biotechnology, tissue engineering has introduced novel solutions to traditional wound healing approaches, particularly demonstrating significant potential in addressing complex or non-healing wounds. One of the key technologies...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Regenerative Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320424002384 |
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| author | Xinran Ding Sujie Xie Wei Zhang Yushu Zhu Dayuan Xu Shuyuan Xian Hanlin Sun Xinya Guo Yixu Li Jianyu Lu Xirui Tong Runzhi Huang Shizhao Ji Zhaofan Xia |
| author_facet | Xinran Ding Sujie Xie Wei Zhang Yushu Zhu Dayuan Xu Shuyuan Xian Hanlin Sun Xinya Guo Yixu Li Jianyu Lu Xirui Tong Runzhi Huang Shizhao Ji Zhaofan Xia |
| author_sort | Xinran Ding |
| collection | DOAJ |
| description | With the continuous advancement of materials science, cell biology, and biotechnology, tissue engineering has introduced novel solutions to traditional wound healing approaches, particularly demonstrating significant potential in addressing complex or non-healing wounds. One of the key technologies in this field, dermal scaffolds, serve as wound coverage materials that mimic the structural framework of the dermis. They primarily assume the function of extracellular matrix, providing space for cell attachment, migration, and proliferation, thus supporting cellular growth and regulating multiple biological processes in healing. Tissue engineering utilizes combinations of natural or synthetic scaffolds, seeded cells, or growth factors to induce distinct effects in angiogenesis, extracellular matrix deposition, and functional recovery. Therefore, various bioengineered dermal scaffolds hold significant potential for clinical translation in wound healing. This review outlines various extracellular matrix molecules utilized in the development of dermal scaffolds, emphasizes recent progress in cell- and growth factor-modified scaffolds, and discusses the challenges and future perspectives in this evolving field. |
| format | Article |
| id | doaj-art-3cf11b10e7e043b187aa82c3f8a29320 |
| institution | DOAJ |
| issn | 2352-3204 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj-art-3cf11b10e7e043b187aa82c3f8a293202025-08-20T02:58:29ZengElsevierRegenerative Therapy2352-32042025-03-012837138210.1016/j.reth.2024.12.018Current application of tissue-engineered dermal scaffolds mimicking the extracellular matrix microenvironment in wound healingXinran Ding0Sujie Xie1Wei Zhang2Yushu Zhu3Dayuan Xu4Shuyuan Xian5Hanlin Sun6Xinya Guo7Yixu Li8Jianyu Lu9Xirui Tong10Runzhi Huang11Shizhao Ji12Zhaofan Xia13Department of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, No. 168 Changhai Road, Shanghai 200433, ChinaDepartment of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, No. 168 Changhai Road, Shanghai 200433, ChinaDepartment of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, No. 168 Changhai Road, Shanghai 200433, ChinaDepartment of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, No. 168 Changhai Road, Shanghai 200433, ChinaDepartment of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, No. 168 Changhai Road, Shanghai 200433, ChinaDepartment of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, No. 168 Changhai Road, Shanghai 200433, ChinaDepartment of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, No. 168 Changhai Road, Shanghai 200433, ChinaDepartment of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, No. 168 Changhai Road, Shanghai 200433, ChinaDepartment of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, No. 168 Changhai Road, Shanghai 200433, ChinaDepartment of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, No. 168 Changhai Road, Shanghai 200433, ChinaDepartment of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, No. 168 Changhai Road, Shanghai 200433, ChinaCorresponding author.; Department of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, No. 168 Changhai Road, Shanghai 200433, ChinaCorresponding author.; Department of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, No. 168 Changhai Road, Shanghai 200433, ChinaCorresponding author. Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China.; Department of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, No. 168 Changhai Road, Shanghai 200433, ChinaWith the continuous advancement of materials science, cell biology, and biotechnology, tissue engineering has introduced novel solutions to traditional wound healing approaches, particularly demonstrating significant potential in addressing complex or non-healing wounds. One of the key technologies in this field, dermal scaffolds, serve as wound coverage materials that mimic the structural framework of the dermis. They primarily assume the function of extracellular matrix, providing space for cell attachment, migration, and proliferation, thus supporting cellular growth and regulating multiple biological processes in healing. Tissue engineering utilizes combinations of natural or synthetic scaffolds, seeded cells, or growth factors to induce distinct effects in angiogenesis, extracellular matrix deposition, and functional recovery. Therefore, various bioengineered dermal scaffolds hold significant potential for clinical translation in wound healing. This review outlines various extracellular matrix molecules utilized in the development of dermal scaffolds, emphasizes recent progress in cell- and growth factor-modified scaffolds, and discusses the challenges and future perspectives in this evolving field.http://www.sciencedirect.com/science/article/pii/S2352320424002384Dermal scaffoldExtracellular matrixTissue engineeringWound healing |
| spellingShingle | Xinran Ding Sujie Xie Wei Zhang Yushu Zhu Dayuan Xu Shuyuan Xian Hanlin Sun Xinya Guo Yixu Li Jianyu Lu Xirui Tong Runzhi Huang Shizhao Ji Zhaofan Xia Current application of tissue-engineered dermal scaffolds mimicking the extracellular matrix microenvironment in wound healing Regenerative Therapy Dermal scaffold Extracellular matrix Tissue engineering Wound healing |
| title | Current application of tissue-engineered dermal scaffolds mimicking the extracellular matrix microenvironment in wound healing |
| title_full | Current application of tissue-engineered dermal scaffolds mimicking the extracellular matrix microenvironment in wound healing |
| title_fullStr | Current application of tissue-engineered dermal scaffolds mimicking the extracellular matrix microenvironment in wound healing |
| title_full_unstemmed | Current application of tissue-engineered dermal scaffolds mimicking the extracellular matrix microenvironment in wound healing |
| title_short | Current application of tissue-engineered dermal scaffolds mimicking the extracellular matrix microenvironment in wound healing |
| title_sort | current application of tissue engineered dermal scaffolds mimicking the extracellular matrix microenvironment in wound healing |
| topic | Dermal scaffold Extracellular matrix Tissue engineering Wound healing |
| url | http://www.sciencedirect.com/science/article/pii/S2352320424002384 |
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