Rearrangement of the liver ubiquitome and NEDDylome in metabolic dysfunction-associated steatotic liver disease

Rearrangement of the liver ubiquitome and NEDDylome in metabolic dysfunction-associated steatotic liver disease

Abstract The remodeling of the liver proteome, driven by dynamic ubiquitin-like post-translational modifications (PTMs) such as ubiquitination and NEDDylation, is a hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD). These PTMs enable rapid adaptation to environmental chall...

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Main Authors: Teresa C. Delgado, Benoît Lectez, Marina Serrano-Maciá, Fernando Lopitz-Otsoa, Leire Uraga-Gracianteparaluceta, Ibon Martínez-Arranz, Jesús M. Arizmendi, Kerman Aloria, Mikel Azkargorta, Félix Elortza, James D. Sutherland, Rosa Barrio, Ugo Mayor, María Luz Martínez-Chantar
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Gut and Liver
Online Access:https://doi.org/10.1038/s44355-025-00032-0
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