Validation of ion chromatographic method for determination of inorganic anions in bottled water
This study validates a method for the determination of anions in drinking water using ion chromatography (IC), with a focus on accuracy, precision, and reliability, aligned with regulatory requirements for water quality monitoring. The method focuses on detecting common anions, including fluoride, c...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association
2025-06-01
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| Series: | Makedonsko Farmacevtski Bilten |
| Subjects: | |
| Online Access: | https://bulletin.mfd.org.mk/volumes/Volume%2071_1/71_1_004.pdf |
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| Summary: | This study validates a method for the determination of anions in drinking water using ion chromatography (IC), with a focus on accuracy, precision, and reliability, aligned with regulatory requirements for water quality monitoring. The method focuses on detecting common anions, including fluoride, chloride, nitrite, nitrate, sulfate, and phosphate, in compliance with international water quality standards. The anions were separated and examined by using a Dionex IonPacTM AS22 column (4 x 250 mm), with a flow rate of 1.2 mL/min, using 4.5 mM Na2CO3 /1.4 mM NaHCO3 as eluent and DS6 heated conductivity detector. The validation of the analytical method was studied in terms of selectivity, linearity, accuracy, sensitivity, precision, and measurement uncertainty. The method demonstrated robust validity, characterized by high selectivity and excellent linearity between 0.9975 and 0.9999. Accuracy ranged from 98.87 to 100.80%, with precision reflected in low RSD values (0.05 – 2.85%). Sensitivity was evident from LOD (0.003 – 0.02 mg/L) and LOQ
(0.009 – 0.05 mg/L) values. Measurement uncertainty was minimal, ranging from 2.43 to 4.88% confirming the method’s reliability for
quantitative analysis. The method has been tested on bottled water samples taken from four different places in North Macedonia (Debar,
Bitola, Kratovo and Gevgelija) during the period May 2023 to April 2024, a time interval for which sufficient information on the quality of drinking water can be obtained. These findings confirm the method’s applicability for routine monitoring of drinking water quality in line with international standards.
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| ISSN: | 1409-8695 1857-8969 |