Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice

Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice

Abstract Background Adipose tissue plays a pivotal role in systemic metabolism and maintaining bodily homeostasis. Exosomes from adipose tissues, known as AT-Exos, are recognized as important messengers in the communication between adipose tissue and other organs. Despite this, the alterations in ex...

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Bibliographic Details
Main Authors: Yun-kai Lin, Yu-fei Pan, Tian-yi Jiang, Yi-bin Chen, Tai-yu Shang, Meng-you Xu, Hui-bo Feng, Yun-han Ma, Ye-xiong Tan, Hong-yang Wang, Li-wei Dong
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Biomedical Science
Subjects:
Adipose tissue
Exosomes
miRNAs
Obesity
Macrophages
SIRPα-CD47
Online Access:https://doi.org/10.1186/s12929-025-01124-y
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