Mediating role of systemic inflammation in the association between volatile organic compounds exposure and periodontitis: NHANES 2011–2014
Abstract Background Volatile organic compounds (VOCs) are ubiquitous environmental pollutants which have been suggested to have adverse effects on human health. While the influence of environmental pollutant exposures on periodontitis has attracted elevating attention in recent years, the epidemiolo...
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2024-10-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-024-05110-y |
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| author | Zhida Dai Zhixiang Zhang Qiaobin Hu Xinyuan Yu Yixi Cao Yian Xia Yingyin Fu Yuxuan Tan Chunxia Jing Chunlei Zhang |
| author_facet | Zhida Dai Zhixiang Zhang Qiaobin Hu Xinyuan Yu Yixi Cao Yian Xia Yingyin Fu Yuxuan Tan Chunxia Jing Chunlei Zhang |
| author_sort | Zhida Dai |
| collection | DOAJ |
| description | Abstract Background Volatile organic compounds (VOCs) are ubiquitous environmental pollutants which have been suggested to have adverse effects on human health. While the influence of environmental pollutant exposures on periodontitis has attracted elevating attention in recent years, the epidemiological evidence on the association between VOCs exposure and periodontitis was scarce. This study aimed to investigate the potential mediating role of systemic inflammation factors in the complex association between VOCs exposure and periodontitis. Methods Utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2011–2014, we examined the impacts of VOCs exposure on periodontitis. Concentrations of urinary metabolites of VOCs (mVOCs) were measured using electrospray tandem mass spectrometry to evaluate internal VOCs exposure. Multivariable logistic regression, restricted cubic spline regression (RCS), Bayesian kernel machine regression (BKMR) and Quantile g-computation (QGC) models were performed to investigate the impacts of VOCs exposure on periodontitis. Mediation models were applied to assess the mediated effects of systemic inflammation on the association between mixed VOCs exposure and periodontitis. Besides, we analyzed the association between mixed VOCs exposure and periodontitis in stratified age, gender, and smoking status subgroups. Results 1,551 participants were ultimately included for further analyses, of whom 45.20% suffering from periodontitis. Multivariable logistic regression and RCS identified positive associations between single urinary mVOCs and periodontitis (P < 0.05). Notably, BKMR and QGC models suggested that mixed VOCs exposure was significantly associated with periodontitis, with 2-Aminothiazoline-4-carboxylic acid (ATCA) contributing the most (conditional posterior inclusion probability = 0.997). Moreover, systemic inflammation markers (leukocyte and lymphocyte counts) were found to partly mediate the association between VOCs exposure and periodontitis (P < 0.05). No interaction effect was identified between mixed VOCs exposure and periodontitis in age, gender and smoking status subgroups (P > 0.05). Conclusion This study demonstrated a positive association between VOCs exposure and periodontitis, which was potentially mediated by systemic inflammation factors. Further longitudinal researches are demanded to clarify the underlying mechanisms. |
| format | Article |
| id | doaj-art-3ceb47bed43a43f1bed738b559b931e2 |
| institution | OA Journals |
| issn | 1472-6831 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
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| series | BMC Oral Health |
| spelling | doaj-art-3ceb47bed43a43f1bed738b559b931e22025-08-20T02:18:32ZengBMCBMC Oral Health1472-68312024-10-0124111310.1186/s12903-024-05110-yMediating role of systemic inflammation in the association between volatile organic compounds exposure and periodontitis: NHANES 2011–2014Zhida Dai0Zhixiang Zhang1Qiaobin Hu2Xinyuan Yu3Yixi Cao4Yian Xia5Yingyin Fu6Yuxuan Tan7Chunxia Jing8Chunlei Zhang9School of Stomatology, Jinan UniversitySchool of Stomatology, Jinan UniversitySchool of Stomatology, Jinan UniversitySchool of Stomatology, Jinan UniversitySchool of Stomatology, Jinan UniversitySchool of Stomatology, Jinan UniversityDepartment of Preventive Medicine and Public Health, School of Medicine, Jinan UniversityDepartment of Preventive Medicine and Public Health, School of Medicine, Jinan UniversityDepartment of Preventive Medicine and Public Health, School of Medicine, Jinan UniversitySchool of Stomatology, Jinan UniversityAbstract Background Volatile organic compounds (VOCs) are ubiquitous environmental pollutants which have been suggested to have adverse effects on human health. While the influence of environmental pollutant exposures on periodontitis has attracted elevating attention in recent years, the epidemiological evidence on the association between VOCs exposure and periodontitis was scarce. This study aimed to investigate the potential mediating role of systemic inflammation factors in the complex association between VOCs exposure and periodontitis. Methods Utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2011–2014, we examined the impacts of VOCs exposure on periodontitis. Concentrations of urinary metabolites of VOCs (mVOCs) were measured using electrospray tandem mass spectrometry to evaluate internal VOCs exposure. Multivariable logistic regression, restricted cubic spline regression (RCS), Bayesian kernel machine regression (BKMR) and Quantile g-computation (QGC) models were performed to investigate the impacts of VOCs exposure on periodontitis. Mediation models were applied to assess the mediated effects of systemic inflammation on the association between mixed VOCs exposure and periodontitis. Besides, we analyzed the association between mixed VOCs exposure and periodontitis in stratified age, gender, and smoking status subgroups. Results 1,551 participants were ultimately included for further analyses, of whom 45.20% suffering from periodontitis. Multivariable logistic regression and RCS identified positive associations between single urinary mVOCs and periodontitis (P < 0.05). Notably, BKMR and QGC models suggested that mixed VOCs exposure was significantly associated with periodontitis, with 2-Aminothiazoline-4-carboxylic acid (ATCA) contributing the most (conditional posterior inclusion probability = 0.997). Moreover, systemic inflammation markers (leukocyte and lymphocyte counts) were found to partly mediate the association between VOCs exposure and periodontitis (P < 0.05). No interaction effect was identified between mixed VOCs exposure and periodontitis in age, gender and smoking status subgroups (P > 0.05). Conclusion This study demonstrated a positive association between VOCs exposure and periodontitis, which was potentially mediated by systemic inflammation factors. Further longitudinal researches are demanded to clarify the underlying mechanisms.https://doi.org/10.1186/s12903-024-05110-yPeriodontitisVolatile organic compounds (VOCs)InflammationNational Health and Nutrition Examination Survey (NHANES)Bayesian kernel machine regression (BKMR)Quantile g-computation (QGC) |
| spellingShingle | Zhida Dai Zhixiang Zhang Qiaobin Hu Xinyuan Yu Yixi Cao Yian Xia Yingyin Fu Yuxuan Tan Chunxia Jing Chunlei Zhang Mediating role of systemic inflammation in the association between volatile organic compounds exposure and periodontitis: NHANES 2011–2014 BMC Oral Health Periodontitis Volatile organic compounds (VOCs) Inflammation National Health and Nutrition Examination Survey (NHANES) Bayesian kernel machine regression (BKMR) Quantile g-computation (QGC) |
| title | Mediating role of systemic inflammation in the association between volatile organic compounds exposure and periodontitis: NHANES 2011–2014 |
| title_full | Mediating role of systemic inflammation in the association between volatile organic compounds exposure and periodontitis: NHANES 2011–2014 |
| title_fullStr | Mediating role of systemic inflammation in the association between volatile organic compounds exposure and periodontitis: NHANES 2011–2014 |
| title_full_unstemmed | Mediating role of systemic inflammation in the association between volatile organic compounds exposure and periodontitis: NHANES 2011–2014 |
| title_short | Mediating role of systemic inflammation in the association between volatile organic compounds exposure and periodontitis: NHANES 2011–2014 |
| title_sort | mediating role of systemic inflammation in the association between volatile organic compounds exposure and periodontitis nhanes 2011 2014 |
| topic | Periodontitis Volatile organic compounds (VOCs) Inflammation National Health and Nutrition Examination Survey (NHANES) Bayesian kernel machine regression (BKMR) Quantile g-computation (QGC) |
| url | https://doi.org/10.1186/s12903-024-05110-y |
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