CD103-Negative Hairy Cell Leukemia: A Case Report From University Teaching Hospital, Zambia
Hairy cell leukemia (HCL) is among a group of mature lymphoid B-cell disorders characterized by the identification of hairy cells and a unique genetic profile. Detection of CD103 expression on flow cytometry is the key in enumerating the immunologic score for diagnosing HCL. For a disease that is mo...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/carm/7084757 |
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| author | Natasha Mupeta Kaweme Sahar Mounir Nagib Butress Inonge Akekelwa Sumbukeni Francis Kowa Hamakwa Muluti Mantina Charles Kapela Mwandama |
| author_facet | Natasha Mupeta Kaweme Sahar Mounir Nagib Butress Inonge Akekelwa Sumbukeni Francis Kowa Hamakwa Muluti Mantina Charles Kapela Mwandama |
| author_sort | Natasha Mupeta Kaweme |
| collection | DOAJ |
| description | Hairy cell leukemia (HCL) is among a group of mature lymphoid B-cell disorders characterized by the identification of hairy cells and a unique genetic profile. Detection of CD103 expression on flow cytometry is the key in enumerating the immunologic score for diagnosing HCL. For a disease that is more prevalent in Caucasians and less common in African populations, we report an unusual case of CD103-negative classical HCL in a 43-year-old African male, who presented with refractory anemia, thrombocytopenia, and splenomegaly. In patients with refractory anemia, it is crucial to consider investigating HCL, as this may influence therapeutic decisions and, consequently, overall patient outcomes. |
| format | Article |
| id | doaj-art-3ce8e034128e48bb95603ff2e0756402 |
| institution | DOAJ |
| issn | 1687-9635 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-3ce8e034128e48bb95603ff2e07564022025-08-20T03:12:53ZengWileyCase Reports in Medicine1687-96352025-01-01202510.1155/carm/7084757CD103-Negative Hairy Cell Leukemia: A Case Report From University Teaching Hospital, ZambiaNatasha Mupeta Kaweme0Sahar Mounir Nagib Butress1Inonge Akekelwa2Sumbukeni Francis Kowa3Hamakwa Muluti Mantina4Charles Kapela Mwandama5Department of Pathology and MicrobiologyDepartment of Pathology and MicrobiologyDepartment of Pathology and MicrobiologyDepartment of Pathology and MicrobiologyDepartment of Pathology and MicrobiologyDepartment of Internal MedicineHairy cell leukemia (HCL) is among a group of mature lymphoid B-cell disorders characterized by the identification of hairy cells and a unique genetic profile. Detection of CD103 expression on flow cytometry is the key in enumerating the immunologic score for diagnosing HCL. For a disease that is more prevalent in Caucasians and less common in African populations, we report an unusual case of CD103-negative classical HCL in a 43-year-old African male, who presented with refractory anemia, thrombocytopenia, and splenomegaly. In patients with refractory anemia, it is crucial to consider investigating HCL, as this may influence therapeutic decisions and, consequently, overall patient outcomes.http://dx.doi.org/10.1155/carm/7084757 |
| spellingShingle | Natasha Mupeta Kaweme Sahar Mounir Nagib Butress Inonge Akekelwa Sumbukeni Francis Kowa Hamakwa Muluti Mantina Charles Kapela Mwandama CD103-Negative Hairy Cell Leukemia: A Case Report From University Teaching Hospital, Zambia Case Reports in Medicine |
| title | CD103-Negative Hairy Cell Leukemia: A Case Report From University Teaching Hospital, Zambia |
| title_full | CD103-Negative Hairy Cell Leukemia: A Case Report From University Teaching Hospital, Zambia |
| title_fullStr | CD103-Negative Hairy Cell Leukemia: A Case Report From University Teaching Hospital, Zambia |
| title_full_unstemmed | CD103-Negative Hairy Cell Leukemia: A Case Report From University Teaching Hospital, Zambia |
| title_short | CD103-Negative Hairy Cell Leukemia: A Case Report From University Teaching Hospital, Zambia |
| title_sort | cd103 negative hairy cell leukemia a case report from university teaching hospital zambia |
| url | http://dx.doi.org/10.1155/carm/7084757 |
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