Evolutionary trade-off and mutational bias could favor transcriptional over translational divergence within paralog pairs.
How changes in the different steps of protein synthesis-transcription, translation and degradation-contribute to differences of protein abundance among genes is not fully understood. There is however accumulating evidence that transcriptional divergence might have a prominent role. Here, we show tha...
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| Language: | English |
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Public Library of Science (PLoS)
2023-05-01
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| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010756&type=printable |
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| author | Simon Aubé Lou Nielly-Thibault Christian R Landry |
| author_facet | Simon Aubé Lou Nielly-Thibault Christian R Landry |
| author_sort | Simon Aubé |
| collection | DOAJ |
| description | How changes in the different steps of protein synthesis-transcription, translation and degradation-contribute to differences of protein abundance among genes is not fully understood. There is however accumulating evidence that transcriptional divergence might have a prominent role. Here, we show that yeast paralogous genes are more divergent in transcription than in translation. We explore two causal mechanisms for this predominance of transcriptional divergence: an evolutionary trade-off between the precision and economy of gene expression and a larger mutational target size for transcription. Performing simulations within a minimal model of post-duplication evolution, we find that both mechanisms are consistent with the observed divergence patterns. We also investigate how additional properties of the effects of mutations on gene expression, such as their asymmetry and correlation across levels of regulation, can shape the evolution of paralogs. Our results highlight the importance of fully characterizing the distributions of mutational effects on transcription and translation. They also show how general trade-offs in cellular processes and mutation bias can have far-reaching evolutionary impacts. |
| format | Article |
| id | doaj-art-3cdf9d10f1fb4589ac8500f76bf96f88 |
| institution | DOAJ |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj-art-3cdf9d10f1fb4589ac8500f76bf96f882025-08-20T03:10:38ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042023-05-01195e101075610.1371/journal.pgen.1010756Evolutionary trade-off and mutational bias could favor transcriptional over translational divergence within paralog pairs.Simon AubéLou Nielly-ThibaultChristian R LandryHow changes in the different steps of protein synthesis-transcription, translation and degradation-contribute to differences of protein abundance among genes is not fully understood. There is however accumulating evidence that transcriptional divergence might have a prominent role. Here, we show that yeast paralogous genes are more divergent in transcription than in translation. We explore two causal mechanisms for this predominance of transcriptional divergence: an evolutionary trade-off between the precision and economy of gene expression and a larger mutational target size for transcription. Performing simulations within a minimal model of post-duplication evolution, we find that both mechanisms are consistent with the observed divergence patterns. We also investigate how additional properties of the effects of mutations on gene expression, such as their asymmetry and correlation across levels of regulation, can shape the evolution of paralogs. Our results highlight the importance of fully characterizing the distributions of mutational effects on transcription and translation. They also show how general trade-offs in cellular processes and mutation bias can have far-reaching evolutionary impacts.https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010756&type=printable |
| spellingShingle | Simon Aubé Lou Nielly-Thibault Christian R Landry Evolutionary trade-off and mutational bias could favor transcriptional over translational divergence within paralog pairs. PLoS Genetics |
| title | Evolutionary trade-off and mutational bias could favor transcriptional over translational divergence within paralog pairs. |
| title_full | Evolutionary trade-off and mutational bias could favor transcriptional over translational divergence within paralog pairs. |
| title_fullStr | Evolutionary trade-off and mutational bias could favor transcriptional over translational divergence within paralog pairs. |
| title_full_unstemmed | Evolutionary trade-off and mutational bias could favor transcriptional over translational divergence within paralog pairs. |
| title_short | Evolutionary trade-off and mutational bias could favor transcriptional over translational divergence within paralog pairs. |
| title_sort | evolutionary trade off and mutational bias could favor transcriptional over translational divergence within paralog pairs |
| url | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010756&type=printable |
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