Peripheral blood heat shock protein 27 correlates with information processing speed and executive function, potentially serving as a marker for mild cognitive impairment in patients with type 2 diabetes mellitus
Abstract Background and aims Previous study found that interleukin 1β (IL-1β) is associated with diabetic cognitive dysfunction. Heat shock protein 27 (HSP27) is one of the factors related to IL-1β associated inflammation. Here, we aim to investigate the role of HSP27 in mild cognitive impairment (M...
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BMC
2025-05-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | https://doi.org/10.1186/s13098-025-01747-z |
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| author | Shufang Yang Haoqiang Zhang Wenwen Zhu Tong Niu Huzaifa Fareeduddin Mohammed Farooqui Jue Wang Mingyue Yang Enlin Liu Shaohua Wang |
| author_facet | Shufang Yang Haoqiang Zhang Wenwen Zhu Tong Niu Huzaifa Fareeduddin Mohammed Farooqui Jue Wang Mingyue Yang Enlin Liu Shaohua Wang |
| author_sort | Shufang Yang |
| collection | DOAJ |
| description | Abstract Background and aims Previous study found that interleukin 1β (IL-1β) is associated with diabetic cognitive dysfunction. Heat shock protein 27 (HSP27) is one of the factors related to IL-1β associated inflammation. Here, we aim to investigate the role of HSP27 in mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus (T2DM). Materials and methods In this study, individuals with T2DM with and without MCI were recruited and categorized into Control and MCI groups. Plasma HSP27 levels were assessed and compared between the Control and MCI groups. Furthermore, the relationship between HSP27 and diabetic dysfunction was elucidated through association and regression analyses. Finally, diagnostic values were determined using ROC curves. Results In humans, individuals with T2DM and MCI exhibit decreased levels of HSP27 compared to those without MCI. Notably, the levels of HSP27 are associated with neuropsychological test scores that reflect cognitive preferences. Additionally, decreased HSP27 levels serve as one of the risk factors for MCI in T2DM patients (OR = 0.355, P = 0.002). Moreover, there is a defined cut-off point for HSP27 in diagnosing MCI, set at 3.51 pg/ml, with a sensitivity of 47.2%, a specificity of 94.4%, and an area under the curve (AUC) of 0.695. Conclusions Generally speaking, HSP27 is linked to cognitive decline in individuals with T2DM. Decreased levels of HSP27 in plasma are identified as both a risk factor for MCI and a potential diagnostic biomarker for MCI in patients with T2DM. The diagnostic value of HSP27 in MCI is primarily reflected in its demonstrated true negative rate. |
| format | Article |
| id | doaj-art-3cddd078d40f49c590884c518fdb4f2b |
| institution | OA Journals |
| issn | 1758-5996 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj-art-3cddd078d40f49c590884c518fdb4f2b2025-08-20T01:53:25ZengBMCDiabetology & Metabolic Syndrome1758-59962025-05-011711910.1186/s13098-025-01747-zPeripheral blood heat shock protein 27 correlates with information processing speed and executive function, potentially serving as a marker for mild cognitive impairment in patients with type 2 diabetes mellitusShufang Yang0Haoqiang Zhang1Wenwen Zhu2Tong Niu3Huzaifa Fareeduddin Mohammed Farooqui4Jue Wang5Mingyue Yang6Enlin Liu7Shaohua Wang8Department of Endocrinology, Affiliated Zhongda Hospital of Southeast UniversityDepartment of Endocrinology, Centre for Leading Medicine and Advanced Technologies of IHM, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of ChinaDepartment of Endocrinology, Affiliated Zhongda Hospital of Southeast UniversityDepartment of Endocrinology, Affiliated Zhongda Hospital of Southeast UniversityDepartment of Endocrinology, Affiliated Zhongda Hospital of Southeast UniversityDepartment of Endocrinology, The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityDepartment of Endocrinology, The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityDepartment of Endocrinology, The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityDepartment of Endocrinology, Affiliated Zhongda Hospital of Southeast UniversityAbstract Background and aims Previous study found that interleukin 1β (IL-1β) is associated with diabetic cognitive dysfunction. Heat shock protein 27 (HSP27) is one of the factors related to IL-1β associated inflammation. Here, we aim to investigate the role of HSP27 in mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus (T2DM). Materials and methods In this study, individuals with T2DM with and without MCI were recruited and categorized into Control and MCI groups. Plasma HSP27 levels were assessed and compared between the Control and MCI groups. Furthermore, the relationship between HSP27 and diabetic dysfunction was elucidated through association and regression analyses. Finally, diagnostic values were determined using ROC curves. Results In humans, individuals with T2DM and MCI exhibit decreased levels of HSP27 compared to those without MCI. Notably, the levels of HSP27 are associated with neuropsychological test scores that reflect cognitive preferences. Additionally, decreased HSP27 levels serve as one of the risk factors for MCI in T2DM patients (OR = 0.355, P = 0.002). Moreover, there is a defined cut-off point for HSP27 in diagnosing MCI, set at 3.51 pg/ml, with a sensitivity of 47.2%, a specificity of 94.4%, and an area under the curve (AUC) of 0.695. Conclusions Generally speaking, HSP27 is linked to cognitive decline in individuals with T2DM. Decreased levels of HSP27 in plasma are identified as both a risk factor for MCI and a potential diagnostic biomarker for MCI in patients with T2DM. The diagnostic value of HSP27 in MCI is primarily reflected in its demonstrated true negative rate.https://doi.org/10.1186/s13098-025-01747-zType 2 diabetes mellitusHeat shock protein 27Mild cognitive impairment |
| spellingShingle | Shufang Yang Haoqiang Zhang Wenwen Zhu Tong Niu Huzaifa Fareeduddin Mohammed Farooqui Jue Wang Mingyue Yang Enlin Liu Shaohua Wang Peripheral blood heat shock protein 27 correlates with information processing speed and executive function, potentially serving as a marker for mild cognitive impairment in patients with type 2 diabetes mellitus Diabetology & Metabolic Syndrome Type 2 diabetes mellitus Heat shock protein 27 Mild cognitive impairment |
| title | Peripheral blood heat shock protein 27 correlates with information processing speed and executive function, potentially serving as a marker for mild cognitive impairment in patients with type 2 diabetes mellitus |
| title_full | Peripheral blood heat shock protein 27 correlates with information processing speed and executive function, potentially serving as a marker for mild cognitive impairment in patients with type 2 diabetes mellitus |
| title_fullStr | Peripheral blood heat shock protein 27 correlates with information processing speed and executive function, potentially serving as a marker for mild cognitive impairment in patients with type 2 diabetes mellitus |
| title_full_unstemmed | Peripheral blood heat shock protein 27 correlates with information processing speed and executive function, potentially serving as a marker for mild cognitive impairment in patients with type 2 diabetes mellitus |
| title_short | Peripheral blood heat shock protein 27 correlates with information processing speed and executive function, potentially serving as a marker for mild cognitive impairment in patients with type 2 diabetes mellitus |
| title_sort | peripheral blood heat shock protein 27 correlates with information processing speed and executive function potentially serving as a marker for mild cognitive impairment in patients with type 2 diabetes mellitus |
| topic | Type 2 diabetes mellitus Heat shock protein 27 Mild cognitive impairment |
| url | https://doi.org/10.1186/s13098-025-01747-z |
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