Advancements in the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: A Comprehensive Review
Hypertrophic cardiomyopathy (HCM) is characterized by excessive growth of myocardial tissue, most commonly due to genetic mutations in sarcomere proteins. This can lead to complications such as heart failure, mitral regurgitation, syncope, arrhythmias, sudden cardiac death, and myocardial ischemia....
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| Language: | English |
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MDPI AG
2024-09-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/11/9/290 |
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| author | Randeep Gill Arsalan Siddiqui Brianna Yee Michael V. DiCaro Nazanin Houshmand Tahir Tak |
| author_facet | Randeep Gill Arsalan Siddiqui Brianna Yee Michael V. DiCaro Nazanin Houshmand Tahir Tak |
| author_sort | Randeep Gill |
| collection | DOAJ |
| description | Hypertrophic cardiomyopathy (HCM) is characterized by excessive growth of myocardial tissue, most commonly due to genetic mutations in sarcomere proteins. This can lead to complications such as heart failure, mitral regurgitation, syncope, arrhythmias, sudden cardiac death, and myocardial ischemia. While we have come a long way in our understanding of the pathophysiology, genetics, and epidemiology of HCM, the past 10 years have seen significant advancements in diagnosis and treatment. As the body of evidence on hypertrophic cardiomyopathy continues to grow, a comprehensive review of the current literature is an invaluable resource in organizing this knowledge. By doing so, the vast progress that has been made thus far will be widely available to all experts in the field. This review provides a comprehensive analysis of the scientific literature, exploring both well-established and cutting-edge diagnostic and therapeutic options. It also presents a unique perspective by incorporating topics such as exercise testing, genetic testing, radiofrequency ablation, risk stratification, and symptomatic management in non-obstructive HCM. Lastly, this review highlights areas where current and future research is at the forefront of innovation in hypertrophic cardiomyopathy. |
| format | Article |
| id | doaj-art-3cd9448f9e5f453ea44d56db8b236e99 |
| institution | OA Journals |
| issn | 2308-3425 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj-art-3cd9448f9e5f453ea44d56db8b236e992025-08-20T01:55:34ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252024-09-0111929010.3390/jcdd11090290Advancements in the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: A Comprehensive ReviewRandeep Gill0Arsalan Siddiqui1Brianna Yee2Michael V. DiCaro3Nazanin Houshmand4Tahir Tak5Department of Internal Medicine, Kirk Kerkorian School of Medicine at UNLV, Las Vegas, NV 89102, USADepartment of Internal Medicine, Kirk Kerkorian School of Medicine at UNLV, Las Vegas, NV 89102, USADepartment of Internal Medicine, Kirk Kerkorian School of Medicine at UNLV, Las Vegas, NV 89102, USADepartment of Internal Medicine, Kirk Kerkorian School of Medicine at UNLV, Las Vegas, NV 89102, USADepartment of Internal Medicine, Kirk Kerkorian School of Medicine at UNLV, Las Vegas, NV 89102, USADepartment of Internal Medicine, Kirk Kerkorian School of Medicine at UNLV, Las Vegas, NV 89102, USAHypertrophic cardiomyopathy (HCM) is characterized by excessive growth of myocardial tissue, most commonly due to genetic mutations in sarcomere proteins. This can lead to complications such as heart failure, mitral regurgitation, syncope, arrhythmias, sudden cardiac death, and myocardial ischemia. While we have come a long way in our understanding of the pathophysiology, genetics, and epidemiology of HCM, the past 10 years have seen significant advancements in diagnosis and treatment. As the body of evidence on hypertrophic cardiomyopathy continues to grow, a comprehensive review of the current literature is an invaluable resource in organizing this knowledge. By doing so, the vast progress that has been made thus far will be widely available to all experts in the field. This review provides a comprehensive analysis of the scientific literature, exploring both well-established and cutting-edge diagnostic and therapeutic options. It also presents a unique perspective by incorporating topics such as exercise testing, genetic testing, radiofrequency ablation, risk stratification, and symptomatic management in non-obstructive HCM. Lastly, this review highlights areas where current and future research is at the forefront of innovation in hypertrophic cardiomyopathy.https://www.mdpi.com/2308-3425/11/9/290alcohol septal ablationheart failurehypertrophic obstructive cardiomyopathymavacamtenmitral valve regurgitationseptal myectomy |
| spellingShingle | Randeep Gill Arsalan Siddiqui Brianna Yee Michael V. DiCaro Nazanin Houshmand Tahir Tak Advancements in the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: A Comprehensive Review Journal of Cardiovascular Development and Disease alcohol septal ablation heart failure hypertrophic obstructive cardiomyopathy mavacamten mitral valve regurgitation septal myectomy |
| title | Advancements in the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: A Comprehensive Review |
| title_full | Advancements in the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: A Comprehensive Review |
| title_fullStr | Advancements in the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: A Comprehensive Review |
| title_full_unstemmed | Advancements in the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: A Comprehensive Review |
| title_short | Advancements in the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: A Comprehensive Review |
| title_sort | advancements in the diagnosis and treatment of hypertrophic cardiomyopathy a comprehensive review |
| topic | alcohol septal ablation heart failure hypertrophic obstructive cardiomyopathy mavacamten mitral valve regurgitation septal myectomy |
| url | https://www.mdpi.com/2308-3425/11/9/290 |
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