Comparing the effect of sedation with dexmedetomidine and propofol on sleep quality of patients after cardiac surgery: A randomized clinical trial
Introduction: Sleep quality is the main concern of patients after cardiac surgery. We compared the effect of two routinely used sedatives on the sleep quality of patients admitted to the intensive care unit (ICU) after cardiovascular surgery. Methods: It is a prospective, controlled, randomized clin...
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Tabriz University of Medical Sciences
2024-09-01
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| Series: | Journal of Cardiovascular and Thoracic Research |
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| Online Access: | https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-16-156.pdf |
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| author | Rasoul Azarfarin Mohsen Ziaei Fard Maryam Ghadimi Yasmin Chaibakhsh Marziyeh Yousefi |
| author_facet | Rasoul Azarfarin Mohsen Ziaei Fard Maryam Ghadimi Yasmin Chaibakhsh Marziyeh Yousefi |
| author_sort | Rasoul Azarfarin |
| collection | DOAJ |
| description | Introduction: Sleep quality is the main concern of patients after cardiac surgery. We compared the effect of two routinely used sedatives on the sleep quality of patients admitted to the intensive care unit (ICU) after cardiovascular surgery. Methods: It is a prospective, controlled, randomized clinical trial. A total of 120 patients, after cardiac surgery were enrolled. During extubating, patients were randomized into two groups: 60 patients received an infusion of dexmedetomidine (precede; 0.5 μg/kg/h), and 60 patients received 50 μg/kg/min propofol for 6 hours. Baseline characteristics were compared between the groups. The patients completed the St. Mary’s Hospital Sleep Questionnaire, and the scores were compared between the groups. Results: The groups were not different in terms of demographics, underlying diseases, smoking/drug abuse/alcohol, number of vessels involved, history of non-cardiac surgery, and mean levels of serum parameters (P>0.05). Most of the medications used were similar between the groups (P>0.05), except calcium channel blockers (more frequently used in the propofol group [P=0.027). The details of surgery were not statistically significant different (P>0.05); but, the mean volume of platelet received after the surgery was higher in propofol group (P=0.03). The propofol group had less problems with last night’s sleep (0 vs 0.1±0.66), felt more clear-headed (4.9±0.6 vs 4.68±0.58, were more satisfied with their last night’s sleep (52.1% vs 47.9%), but spent more time getting into sleep (0.38±1.67 vs 0 ) (P<0.5). Conclusion: The sleep quality of patients under the influence of propofol seemed to be better than dexmedetomidine after cardiac surgery. |
| format | Article |
| id | doaj-art-3cd6561f58c6438395e577b448f324b6 |
| institution | OA Journals |
| issn | 2008-5117 2008-6830 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Tabriz University of Medical Sciences |
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| series | Journal of Cardiovascular and Thoracic Research |
| spelling | doaj-art-3cd6561f58c6438395e577b448f324b62025-08-20T02:32:56ZengTabriz University of Medical SciencesJournal of Cardiovascular and Thoracic Research2008-51172008-68302024-09-0116315616310.34172/jcvtr.33086jcvtr-33086Comparing the effect of sedation with dexmedetomidine and propofol on sleep quality of patients after cardiac surgery: A randomized clinical trialRasoul Azarfarin0Mohsen Ziaei Fard1Maryam Ghadimi2Yasmin Chaibakhsh3Marziyeh Yousefi4Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranIntroduction: Sleep quality is the main concern of patients after cardiac surgery. We compared the effect of two routinely used sedatives on the sleep quality of patients admitted to the intensive care unit (ICU) after cardiovascular surgery. Methods: It is a prospective, controlled, randomized clinical trial. A total of 120 patients, after cardiac surgery were enrolled. During extubating, patients were randomized into two groups: 60 patients received an infusion of dexmedetomidine (precede; 0.5 μg/kg/h), and 60 patients received 50 μg/kg/min propofol for 6 hours. Baseline characteristics were compared between the groups. The patients completed the St. Mary’s Hospital Sleep Questionnaire, and the scores were compared between the groups. Results: The groups were not different in terms of demographics, underlying diseases, smoking/drug abuse/alcohol, number of vessels involved, history of non-cardiac surgery, and mean levels of serum parameters (P>0.05). Most of the medications used were similar between the groups (P>0.05), except calcium channel blockers (more frequently used in the propofol group [P=0.027). The details of surgery were not statistically significant different (P>0.05); but, the mean volume of platelet received after the surgery was higher in propofol group (P=0.03). The propofol group had less problems with last night’s sleep (0 vs 0.1±0.66), felt more clear-headed (4.9±0.6 vs 4.68±0.58, were more satisfied with their last night’s sleep (52.1% vs 47.9%), but spent more time getting into sleep (0.38±1.67 vs 0 ) (P<0.5). Conclusion: The sleep quality of patients under the influence of propofol seemed to be better than dexmedetomidine after cardiac surgery.https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-16-156.pdfdexmedetomidinepropofolsleep qualitycardiac surgery |
| spellingShingle | Rasoul Azarfarin Mohsen Ziaei Fard Maryam Ghadimi Yasmin Chaibakhsh Marziyeh Yousefi Comparing the effect of sedation with dexmedetomidine and propofol on sleep quality of patients after cardiac surgery: A randomized clinical trial Journal of Cardiovascular and Thoracic Research dexmedetomidine propofol sleep quality cardiac surgery |
| title | Comparing the effect of sedation with dexmedetomidine and propofol on sleep quality of patients after cardiac surgery: A randomized clinical trial |
| title_full | Comparing the effect of sedation with dexmedetomidine and propofol on sleep quality of patients after cardiac surgery: A randomized clinical trial |
| title_fullStr | Comparing the effect of sedation with dexmedetomidine and propofol on sleep quality of patients after cardiac surgery: A randomized clinical trial |
| title_full_unstemmed | Comparing the effect of sedation with dexmedetomidine and propofol on sleep quality of patients after cardiac surgery: A randomized clinical trial |
| title_short | Comparing the effect of sedation with dexmedetomidine and propofol on sleep quality of patients after cardiac surgery: A randomized clinical trial |
| title_sort | comparing the effect of sedation with dexmedetomidine and propofol on sleep quality of patients after cardiac surgery a randomized clinical trial |
| topic | dexmedetomidine propofol sleep quality cardiac surgery |
| url | https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-16-156.pdf |
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