Hyperostosis frontalis interna and association of disease control with frontal bone thickness in acromegaly
Abstract Purpose Studies investigating hyperostosis frontalis interna (HFI) in acromegaly are limited. We aimed to investigate HFI and the association of disease control with frontal bone thickness (FBT) in acromegaly. Methods Adult patients with acromegaly were grouped according to the presence of...
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BMC
2025-03-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-025-01904-5 |
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| author | Ihsan Ayhan Ömercan Topaloğlu Taner Bayraktaroğlu |
| author_facet | Ihsan Ayhan Ömercan Topaloğlu Taner Bayraktaroğlu |
| author_sort | Ihsan Ayhan |
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| description | Abstract Purpose Studies investigating hyperostosis frontalis interna (HFI) in acromegaly are limited. We aimed to investigate HFI and the association of disease control with frontal bone thickness (FBT) in acromegaly. Methods Adult patients with acromegaly were grouped according to the presence of HFI on the baseline MRI: Group 1 absent, Group 2 present. We measured FBT, parietal bone thickness (PBT) and occipital bone thickness (OBT) in the mid-sagittal plane on MRI. The changes between first and last measurements were analyzed. We grouped the patients as controlled vs. uncontrolled acromegaly, and as established disease control for at least 5-year vs. 1-5-years. Results Group 1/Group 2 comprised of 23/29 patients, female/male ratio was 34/18, and mean age 55.41(± 14.21) years. Median follow-up duration was 108 months (6-408). FBTfirst (p = 0.001), FBTlast (p < 0.001), PBTlast (p = 0.025), and OBTlast (p = 0.028) were higher in Group 2 than in Group 1. FBTchange, PBTchange, and OBTchange were positive in Group 2 (p < 0.001, p = 0.008, and p = 0.008; respectively). The ratio of patients with FBT(increased) was higher in Group 2 than in Group 1 (p = 0.001). FBTfirst, FBTlast, PBTfirst, PBTlast, OBTfirst, OBTlast, FBTchange, PBTchange and OBTchange were similar in controlled or uncontrolled acromegaly groups. FBTchange and OBTchange were positive in patients with disease control established for at least 5 years (n = 30) (p = 0.027 and p = 0.002, respectively). Conclusion HFI was common in patients with acromegaly. HFI is associated with a continuous increase in FBT, PBT and OBT. HFI, bone thickness, or increase in bone thickness seems independent of disease activity. Since headaches can be related to an increase in bone thickness, patients should be evaluated and graded during baseline imaging. |
| format | Article |
| id | doaj-art-3cd5b6a70dfd4263a28daeb798236ba1 |
| institution | Kabale University |
| issn | 1472-6823 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj-art-3cd5b6a70dfd4263a28daeb798236ba12025-08-20T03:40:49ZengBMCBMC Endocrine Disorders1472-68232025-03-012511810.1186/s12902-025-01904-5Hyperostosis frontalis interna and association of disease control with frontal bone thickness in acromegalyIhsan Ayhan0Ömercan Topaloğlu1Taner Bayraktaroğlu2Internal Medicine Clinics, Zonguldak Atatürk State HospitalDepartment of Endocrinology and Metabolism, Zonguldak Bülent Ecevit University Medical FacultyDepartment of Endocrinology and Metabolism, Zonguldak Bülent Ecevit University Medical FacultyAbstract Purpose Studies investigating hyperostosis frontalis interna (HFI) in acromegaly are limited. We aimed to investigate HFI and the association of disease control with frontal bone thickness (FBT) in acromegaly. Methods Adult patients with acromegaly were grouped according to the presence of HFI on the baseline MRI: Group 1 absent, Group 2 present. We measured FBT, parietal bone thickness (PBT) and occipital bone thickness (OBT) in the mid-sagittal plane on MRI. The changes between first and last measurements were analyzed. We grouped the patients as controlled vs. uncontrolled acromegaly, and as established disease control for at least 5-year vs. 1-5-years. Results Group 1/Group 2 comprised of 23/29 patients, female/male ratio was 34/18, and mean age 55.41(± 14.21) years. Median follow-up duration was 108 months (6-408). FBTfirst (p = 0.001), FBTlast (p < 0.001), PBTlast (p = 0.025), and OBTlast (p = 0.028) were higher in Group 2 than in Group 1. FBTchange, PBTchange, and OBTchange were positive in Group 2 (p < 0.001, p = 0.008, and p = 0.008; respectively). The ratio of patients with FBT(increased) was higher in Group 2 than in Group 1 (p = 0.001). FBTfirst, FBTlast, PBTfirst, PBTlast, OBTfirst, OBTlast, FBTchange, PBTchange and OBTchange were similar in controlled or uncontrolled acromegaly groups. FBTchange and OBTchange were positive in patients with disease control established for at least 5 years (n = 30) (p = 0.027 and p = 0.002, respectively). Conclusion HFI was common in patients with acromegaly. HFI is associated with a continuous increase in FBT, PBT and OBT. HFI, bone thickness, or increase in bone thickness seems independent of disease activity. Since headaches can be related to an increase in bone thickness, patients should be evaluated and graded during baseline imaging.https://doi.org/10.1186/s12902-025-01904-5AcromegalyHyperostosisHyperostosis frontalis InternaBoneFrontal bone |
| spellingShingle | Ihsan Ayhan Ömercan Topaloğlu Taner Bayraktaroğlu Hyperostosis frontalis interna and association of disease control with frontal bone thickness in acromegaly BMC Endocrine Disorders Acromegaly Hyperostosis Hyperostosis frontalis Interna Bone Frontal bone |
| title | Hyperostosis frontalis interna and association of disease control with frontal bone thickness in acromegaly |
| title_full | Hyperostosis frontalis interna and association of disease control with frontal bone thickness in acromegaly |
| title_fullStr | Hyperostosis frontalis interna and association of disease control with frontal bone thickness in acromegaly |
| title_full_unstemmed | Hyperostosis frontalis interna and association of disease control with frontal bone thickness in acromegaly |
| title_short | Hyperostosis frontalis interna and association of disease control with frontal bone thickness in acromegaly |
| title_sort | hyperostosis frontalis interna and association of disease control with frontal bone thickness in acromegaly |
| topic | Acromegaly Hyperostosis Hyperostosis frontalis Interna Bone Frontal bone |
| url | https://doi.org/10.1186/s12902-025-01904-5 |
| work_keys_str_mv | AT ihsanayhan hyperostosisfrontalisinternaandassociationofdiseasecontrolwithfrontalbonethicknessinacromegaly AT omercantopaloglu hyperostosisfrontalisinternaandassociationofdiseasecontrolwithfrontalbonethicknessinacromegaly AT tanerbayraktaroglu hyperostosisfrontalisinternaandassociationofdiseasecontrolwithfrontalbonethicknessinacromegaly |