Immune Dysregulation after Cardiothoracic Surgery and Incidental Thymectomy: Maintenance of Regulatory T Cells despite Impaired Thymopoiesis
Thymectomy is performed in infants during cardiothoracic surgery leaving many patients with reduced thympopoiesis. An association between immune disorders and regulatory T cells (Treg) after incidental thymectomy has not been investigated. Questionnaires soliciting symptoms of atopic or autoimmune d...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/915864 |
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| author | Nancy J. Halnon Paige Cooper Diana Yu Hui Chen M. Ines Boechat Christel H. Uittenbogaart |
| author_facet | Nancy J. Halnon Paige Cooper Diana Yu Hui Chen M. Ines Boechat Christel H. Uittenbogaart |
| author_sort | Nancy J. Halnon |
| collection | DOAJ |
| description | Thymectomy is performed in infants during cardiothoracic surgery leaving many patients with reduced thympopoiesis. An association between immune disorders and regulatory T cells (Treg) after incidental thymectomy has not been investigated. Questionnaires soliciting symptoms of atopic or autoimmune disease and biomarkers were measured in children and adults with congenital heart disease and either reduced or preserved thymopoiesis. Tregs were examined. Atopic or autoimmune-like symptoms and elevated anti-dsDNA antibodies were common after surgery in individuals with low thymopoiesis. Total Treg number and function were maintained but with fewer naïve Treg. TCR spectratypes were similar to other memory T cells. These data suggest that thymectomy does not reduce total Treg number but homeostasis is affected with reduced naïve Treg. Prevalence of autoimmune or atopic symptoms after surgery is not associated with total number or proportion of Tregs but appears to be due to otherwise unknown factors that may include altered Treg homeostasis. |
| format | Article |
| id | doaj-art-3ccca0da110e41a780b1cfc7cc3a7949 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-3ccca0da110e41a780b1cfc7cc3a79492025-02-03T05:50:19ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/915864915864Immune Dysregulation after Cardiothoracic Surgery and Incidental Thymectomy: Maintenance of Regulatory T Cells despite Impaired ThymopoiesisNancy J. Halnon0Paige Cooper1Diana Yu Hui Chen2M. Ines Boechat3Christel H. Uittenbogaart4Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USADepartment of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USADepartment of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USADepartment of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USADepartment of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USAThymectomy is performed in infants during cardiothoracic surgery leaving many patients with reduced thympopoiesis. An association between immune disorders and regulatory T cells (Treg) after incidental thymectomy has not been investigated. Questionnaires soliciting symptoms of atopic or autoimmune disease and biomarkers were measured in children and adults with congenital heart disease and either reduced or preserved thymopoiesis. Tregs were examined. Atopic or autoimmune-like symptoms and elevated anti-dsDNA antibodies were common after surgery in individuals with low thymopoiesis. Total Treg number and function were maintained but with fewer naïve Treg. TCR spectratypes were similar to other memory T cells. These data suggest that thymectomy does not reduce total Treg number but homeostasis is affected with reduced naïve Treg. Prevalence of autoimmune or atopic symptoms after surgery is not associated with total number or proportion of Tregs but appears to be due to otherwise unknown factors that may include altered Treg homeostasis.http://dx.doi.org/10.1155/2011/915864 |
| spellingShingle | Nancy J. Halnon Paige Cooper Diana Yu Hui Chen M. Ines Boechat Christel H. Uittenbogaart Immune Dysregulation after Cardiothoracic Surgery and Incidental Thymectomy: Maintenance of Regulatory T Cells despite Impaired Thymopoiesis Clinical and Developmental Immunology |
| title | Immune Dysregulation after Cardiothoracic Surgery and Incidental Thymectomy: Maintenance of Regulatory T Cells despite Impaired Thymopoiesis |
| title_full | Immune Dysregulation after Cardiothoracic Surgery and Incidental Thymectomy: Maintenance of Regulatory T Cells despite Impaired Thymopoiesis |
| title_fullStr | Immune Dysregulation after Cardiothoracic Surgery and Incidental Thymectomy: Maintenance of Regulatory T Cells despite Impaired Thymopoiesis |
| title_full_unstemmed | Immune Dysregulation after Cardiothoracic Surgery and Incidental Thymectomy: Maintenance of Regulatory T Cells despite Impaired Thymopoiesis |
| title_short | Immune Dysregulation after Cardiothoracic Surgery and Incidental Thymectomy: Maintenance of Regulatory T Cells despite Impaired Thymopoiesis |
| title_sort | immune dysregulation after cardiothoracic surgery and incidental thymectomy maintenance of regulatory t cells despite impaired thymopoiesis |
| url | http://dx.doi.org/10.1155/2011/915864 |
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