CORONARY ATHEROSCLEROSIS FACTORS IN PATIENTS WITH STABLE EFFORT ANGINA AND METABOLIC SYNDROME
The effects of lipid profile (LP) parameters on endothelium-dependent vasodilatation were studied in patients with coronary heart disease (CHD) and metabolic syndrome during the lipid load (LL) test. CHD diagnosis was confirmed by selective coronary angiography (CAG). According to CAG results, all p...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2010-06-01
|
| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1453 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849688648507719680 |
|---|---|
| author | T. V. Krovyakova P. A. Lebedev |
| author_facet | T. V. Krovyakova P. A. Lebedev |
| author_sort | T. V. Krovyakova |
| collection | DOAJ |
| description | The effects of lipid profile (LP) parameters on endothelium-dependent vasodilatation were studied in patients with coronary heart disease (CHD) and metabolic syndrome during the lipid load (LL) test. CHD diagnosis was confirmed by selective coronary angiography (CAG). According to CAG results, all participants were divided into 2 groups: Group 1 – without coronary artery (CA) stenosis, or with one-vessel CA stenosis <50%; and Group 2 – with CA stenosis >50% in 2 or more vessels. In Group 2, low-density lipoprotein cholesterol (LDL-CH) levels were significantly higher at baseline and 6 hours after the LL test, while atherogenicity index (AI) was significantly higher after the LL test. In addition, for both groups, fasting triglyceride (TG) levels were higher than normal, doubling after the LL test. At baseline, endothelial function (EF) parameters were lower than normal in both groups. The LL test resulted in vasospastic reaction, with a significantly greater EF reduction among Group 2 patients. Therefore, this test of endothelium-dependent vasodilatation provides an opportunity to identify the patients with more advanced coronary atherosclerosis. |
| format | Article |
| id | doaj-art-3cc671dd66ee4eb3abd62724488b69dc |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2010-06-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-3cc671dd66ee4eb3abd62724488b69dc2025-08-20T03:21:54Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202010-06-010312151241CORONARY ATHEROSCLEROSIS FACTORS IN PATIENTS WITH STABLE EFFORT ANGINA AND METABOLIC SYNDROMET. V. Krovyakova0P. A. Lebedev1ГОУ ВПО Самарский государственный медицинский университет, Кафедра терапии ИПО, СамараГОУ ВПО Самарский государственный медицинский университет, Кафедра терапии ИПО, СамараThe effects of lipid profile (LP) parameters on endothelium-dependent vasodilatation were studied in patients with coronary heart disease (CHD) and metabolic syndrome during the lipid load (LL) test. CHD diagnosis was confirmed by selective coronary angiography (CAG). According to CAG results, all participants were divided into 2 groups: Group 1 – without coronary artery (CA) stenosis, or with one-vessel CA stenosis <50%; and Group 2 – with CA stenosis >50% in 2 or more vessels. In Group 2, low-density lipoprotein cholesterol (LDL-CH) levels were significantly higher at baseline and 6 hours after the LL test, while atherogenicity index (AI) was significantly higher after the LL test. In addition, for both groups, fasting triglyceride (TG) levels were higher than normal, doubling after the LL test. At baseline, endothelial function (EF) parameters were lower than normal in both groups. The LL test resulted in vasospastic reaction, with a significantly greater EF reduction among Group 2 patients. Therefore, this test of endothelium-dependent vasodilatation provides an opportunity to identify the patients with more advanced coronary atherosclerosis.https://russjcardiol.elpub.ru/jour/article/view/1453stable effort anginametabolic syndromecoronary syndromecoronary atherosclerosismarkersangiography |
| spellingShingle | T. V. Krovyakova P. A. Lebedev CORONARY ATHEROSCLEROSIS FACTORS IN PATIENTS WITH STABLE EFFORT ANGINA AND METABOLIC SYNDROME Российский кардиологический журнал stable effort angina metabolic syndrome coronary syndrome coronary atherosclerosis markers angiography |
| title | CORONARY ATHEROSCLEROSIS FACTORS IN PATIENTS WITH STABLE EFFORT ANGINA AND METABOLIC SYNDROME |
| title_full | CORONARY ATHEROSCLEROSIS FACTORS IN PATIENTS WITH STABLE EFFORT ANGINA AND METABOLIC SYNDROME |
| title_fullStr | CORONARY ATHEROSCLEROSIS FACTORS IN PATIENTS WITH STABLE EFFORT ANGINA AND METABOLIC SYNDROME |
| title_full_unstemmed | CORONARY ATHEROSCLEROSIS FACTORS IN PATIENTS WITH STABLE EFFORT ANGINA AND METABOLIC SYNDROME |
| title_short | CORONARY ATHEROSCLEROSIS FACTORS IN PATIENTS WITH STABLE EFFORT ANGINA AND METABOLIC SYNDROME |
| title_sort | coronary atherosclerosis factors in patients with stable effort angina and metabolic syndrome |
| topic | stable effort angina metabolic syndrome coronary syndrome coronary atherosclerosis markers angiography |
| url | https://russjcardiol.elpub.ru/jour/article/view/1453 |
| work_keys_str_mv | AT tvkrovyakova coronaryatherosclerosisfactorsinpatientswithstableeffortanginaandmetabolicsyndrome AT palebedev coronaryatherosclerosisfactorsinpatientswithstableeffortanginaandmetabolicsyndrome |