<sup>18</sup>F-FDG PET/CT in the Diagnosis of Cervical Cancer
Positron emission tomography coupled with computed tomography (PET/CT) has proven to be highly informative in the diagnosis of various malignant tumours. PET/CT examination takes into account biological and morphological data, which allow accurate tumour localisation and full staging of the disease,...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)
2022-12-01
|
| Series: | Регуляторные исследования и экспертиза лекарственных средств |
| Subjects: | |
| Online Access: | https://www.vedomostincesmp.ru/jour/article/view/510 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849249618278219776 |
|---|---|
| author | A. V. Leontyev M. M. Khodzhibekova A. I. Khalimon M. T. Kuliev G. F. Khamadeeva T. L. Antonevskaya T. N. Lazutina A. D. Kaprin |
| author_facet | A. V. Leontyev M. M. Khodzhibekova A. I. Khalimon M. T. Kuliev G. F. Khamadeeva T. L. Antonevskaya T. N. Lazutina A. D. Kaprin |
| author_sort | A. V. Leontyev |
| collection | DOAJ |
| description | Positron emission tomography coupled with computed tomography (PET/CT) has proven to be highly informative in the diagnosis of various malignant tumours. PET/CT examination takes into account biological and morphological data, which allow accurate tumour localisation and full staging of the disease, respectively. Cervical cancer (CC) is one of the most common, high-mortality cancers in women. The effectiveness of CC treatment depends on early diagnosis, which is connected to the assessment of local tumour spread and metastatic lymph node involvement and to the detection of disease recurrence. The aim of the study was to analyse the possibility of using PET/CT with 18F-FDG for the diagnosis of CC and the evaluation of treatment effectiveness. Additionally, the study aimed to analyse the potential of using other radiopharmaceuticals as biomarkers for the assessment of tumour response. Cervical malignancies are characterised by high glycolytic activity, which explains the superiority of 18F-FDG PET/CT over other traditional imaging methods in comprehensive diagnosis of patients with CC and, especially, in detecting nodal involvement and distant metastases. Also, 18F-FDG PET/CT plays an important part in the assessment of treatment effectiveness in CC patients. Further development of 18F-FDG PET/CT potential in the visualisation of malignant cervical lesions is associated with investigating the possibilities of using other specific radiopharmaceuticals to obtain information about the biological processes that support tumour cell growth: metabolism, proliferative activity, and oxygenation. |
| format | Article |
| id | doaj-art-3cc4276a283c4905a31fcb02f687e83b |
| institution | Kabale University |
| issn | 3034-3062 3034-3453 |
| language | Russian |
| publishDate | 2022-12-01 |
| publisher | Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’) |
| record_format | Article |
| series | Регуляторные исследования и экспертиза лекарственных средств |
| spelling | doaj-art-3cc4276a283c4905a31fcb02f687e83b2025-08-20T03:57:31ZrusFederal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)Регуляторные исследования и экспертиза лекарственных средств3034-30623034-34532022-12-0112444445410.30895/1991-2919-2022-12-4-444-454362<sup>18</sup>F-FDG PET/CT in the Diagnosis of Cervical CancerA. V. Leontyev0M. M. Khodzhibekova1A. I. Khalimon2M. T. Kuliev3G. F. Khamadeeva4T. L. Antonevskaya5T. N. Lazutina6A. D. Kaprin7P. Hertsen Moscow Oncology Research Institute, National Medical Research Radiological CentreP. Hertsen Moscow Oncology Research Institute, National Medical Research Radiological CentreP. Hertsen Moscow Oncology Research Institute, National Medical Research Radiological CentreP. Hertsen Moscow Oncology Research Institute, National Medical Research Radiological CentreP. Hertsen Moscow Oncology Research Institute, National Medical Research Radiological CentreP. Hertsen Moscow Oncology Research Institute, National Medical Research Radiological CentreP. Hertsen Moscow Oncology Research Institute, National Medical Research Radiological CentreNational Medical Research Radiological CentrePositron emission tomography coupled with computed tomography (PET/CT) has proven to be highly informative in the diagnosis of various malignant tumours. PET/CT examination takes into account biological and morphological data, which allow accurate tumour localisation and full staging of the disease, respectively. Cervical cancer (CC) is one of the most common, high-mortality cancers in women. The effectiveness of CC treatment depends on early diagnosis, which is connected to the assessment of local tumour spread and metastatic lymph node involvement and to the detection of disease recurrence. The aim of the study was to analyse the possibility of using PET/CT with 18F-FDG for the diagnosis of CC and the evaluation of treatment effectiveness. Additionally, the study aimed to analyse the potential of using other radiopharmaceuticals as biomarkers for the assessment of tumour response. Cervical malignancies are characterised by high glycolytic activity, which explains the superiority of 18F-FDG PET/CT over other traditional imaging methods in comprehensive diagnosis of patients with CC and, especially, in detecting nodal involvement and distant metastases. Also, 18F-FDG PET/CT plays an important part in the assessment of treatment effectiveness in CC patients. Further development of 18F-FDG PET/CT potential in the visualisation of malignant cervical lesions is associated with investigating the possibilities of using other specific radiopharmaceuticals to obtain information about the biological processes that support tumour cell growth: metabolism, proliferative activity, and oxygenation.https://www.vedomostincesmp.ru/jour/article/view/510pet/ct<sup>18</sup>f-fdgradiopharmaceutical productcervical cancer |
| spellingShingle | A. V. Leontyev M. M. Khodzhibekova A. I. Khalimon M. T. Kuliev G. F. Khamadeeva T. L. Antonevskaya T. N. Lazutina A. D. Kaprin <sup>18</sup>F-FDG PET/CT in the Diagnosis of Cervical Cancer Регуляторные исследования и экспертиза лекарственных средств pet/ct <sup>18</sup>f-fdg radiopharmaceutical product cervical cancer |
| title | <sup>18</sup>F-FDG PET/CT in the Diagnosis of Cervical Cancer |
| title_full | <sup>18</sup>F-FDG PET/CT in the Diagnosis of Cervical Cancer |
| title_fullStr | <sup>18</sup>F-FDG PET/CT in the Diagnosis of Cervical Cancer |
| title_full_unstemmed | <sup>18</sup>F-FDG PET/CT in the Diagnosis of Cervical Cancer |
| title_short | <sup>18</sup>F-FDG PET/CT in the Diagnosis of Cervical Cancer |
| title_sort | sup 18 sup f fdg pet ct in the diagnosis of cervical cancer |
| topic | pet/ct <sup>18</sup>f-fdg radiopharmaceutical product cervical cancer |
| url | https://www.vedomostincesmp.ru/jour/article/view/510 |
| work_keys_str_mv | AT avleontyev sup18supffdgpetctinthediagnosisofcervicalcancer AT mmkhodzhibekova sup18supffdgpetctinthediagnosisofcervicalcancer AT aikhalimon sup18supffdgpetctinthediagnosisofcervicalcancer AT mtkuliev sup18supffdgpetctinthediagnosisofcervicalcancer AT gfkhamadeeva sup18supffdgpetctinthediagnosisofcervicalcancer AT tlantonevskaya sup18supffdgpetctinthediagnosisofcervicalcancer AT tnlazutina sup18supffdgpetctinthediagnosisofcervicalcancer AT adkaprin sup18supffdgpetctinthediagnosisofcervicalcancer |