MOS is a novel genetic marker for human early embryonic arrest and fragmentation
Abstract Early embryonic arrest and fragmentation (EEAF) is a common phenotype observed in in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles. The phenotype causes female infertility and recurrent failed IVF/ICSI attempts. However, the molecular mechanisms behind EEAF rem...
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| Format: | Article |
| Language: | English |
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Springer Nature
2021-11-01
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| Series: | EMBO Molecular Medicine |
| Online Access: | https://doi.org/10.15252/emmm.202115323 |
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| author | Lei Wang Qing Sang |
| author_facet | Lei Wang Qing Sang |
| author_sort | Lei Wang |
| collection | DOAJ |
| description | Abstract Early embryonic arrest and fragmentation (EEAF) is a common phenotype observed in in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles. The phenotype causes female infertility and recurrent failed IVF/ICSI attempts. However, the molecular mechanisms behind EEAF remain largely unknown. In this issue of EMBO Molecular Medicine, Zhang et al (2021) present the novel causative gene MOS in patients with the EEAF phenotype. The relationship between MOS variants and human EEAF is comprehensively established through a series of in vitro and in vivo experiments, thus clarifying the role of MOS during human oocyte maturation and early embryo development. These findings suggest that MOS is a new diagnostic marker of EEAF and is a potential therapeutic target for treatment of EEAF patients. |
| format | Article |
| id | doaj-art-3cc1dbe290b84187b62afd7fa2cc22bf |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2021-11-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-3cc1dbe290b84187b62afd7fa2cc22bf2025-08-20T04:03:03ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842021-11-0113121310.15252/emmm.202115323MOS is a novel genetic marker for human early embryonic arrest and fragmentationLei Wang0Qing Sang1Institute of Pediatrics, Children’s Hospital of Fudan University, the Institutes of Biomedical Sciences, and the State Key Laboratory of Genetic Engineering, Fudan UniversityInstitute of Pediatrics, Children’s Hospital of Fudan University, the Institutes of Biomedical Sciences, and the State Key Laboratory of Genetic Engineering, Fudan UniversityAbstract Early embryonic arrest and fragmentation (EEAF) is a common phenotype observed in in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles. The phenotype causes female infertility and recurrent failed IVF/ICSI attempts. However, the molecular mechanisms behind EEAF remain largely unknown. In this issue of EMBO Molecular Medicine, Zhang et al (2021) present the novel causative gene MOS in patients with the EEAF phenotype. The relationship between MOS variants and human EEAF is comprehensively established through a series of in vitro and in vivo experiments, thus clarifying the role of MOS during human oocyte maturation and early embryo development. These findings suggest that MOS is a new diagnostic marker of EEAF and is a potential therapeutic target for treatment of EEAF patients.https://doi.org/10.15252/emmm.202115323 |
| spellingShingle | Lei Wang Qing Sang MOS is a novel genetic marker for human early embryonic arrest and fragmentation EMBO Molecular Medicine |
| title | MOS is a novel genetic marker for human early embryonic arrest and fragmentation |
| title_full | MOS is a novel genetic marker for human early embryonic arrest and fragmentation |
| title_fullStr | MOS is a novel genetic marker for human early embryonic arrest and fragmentation |
| title_full_unstemmed | MOS is a novel genetic marker for human early embryonic arrest and fragmentation |
| title_short | MOS is a novel genetic marker for human early embryonic arrest and fragmentation |
| title_sort | mos is a novel genetic marker for human early embryonic arrest and fragmentation |
| url | https://doi.org/10.15252/emmm.202115323 |
| work_keys_str_mv | AT leiwang mosisanovelgeneticmarkerforhumanearlyembryonicarrestandfragmentation AT qingsang mosisanovelgeneticmarkerforhumanearlyembryonicarrestandfragmentation |