Protective effects of wogonin in the treatment of central nervous system and degenerative diseases
Wogonin, an O-methylated flavonoid extracted from Scutellaria baicalensis, has demonstrated profound neuroprotective effects in a range of central nervous system (CNS) diseases. This review elucidates the pharmacological mechanisms underlying the protective effects of wogonin in CNS diseases, includ...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025000140 |
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| author | Qingan Fu Qingyun Yu Hongdan Luo Zhekang Liu Xiaowei Ma Huijian Wang Zhijuan Cheng |
| author_facet | Qingan Fu Qingyun Yu Hongdan Luo Zhekang Liu Xiaowei Ma Huijian Wang Zhijuan Cheng |
| author_sort | Qingan Fu |
| collection | DOAJ |
| description | Wogonin, an O-methylated flavonoid extracted from Scutellaria baicalensis, has demonstrated profound neuroprotective effects in a range of central nervous system (CNS) diseases. This review elucidates the pharmacological mechanisms underlying the protective effects of wogonin in CNS diseases, including ischemic stroke, hemorrhagic stroke, traumatic brain injury, epilepsy, anxiety, neurodegenerative diseases, and CNS infections. Wogonin modulates key signaling pathways, such as the MAPK, NF-κB, and ROS pathways, contributing to its anti-inflammatory, antioxidant, and antiapoptotic properties. In ischemic stroke models, wogonin reduces infarct size and enhances neurological outcomes by mitigating inflammation and oxidative stress. For patients with hemorrhagic stroke and traumatic brain injury, it accelerates hematoma regression, mitigates secondary brain damage, and promotes neurogenesis, making it an entirely new treatment option for patients with limited access to this type of therapy. Its anticonvulsant and anxiolytic effects are mediated through GABA-A receptor modulation. Moreover, wogonin shows promise in treating neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease by promoting autophagy and reducing neuroinflammation. Additionally, it exhibits antiviral properties, offering potential benefits against CNS infections. Despite extensive preclinical evidence, further clinical studies are warranted to confirm its efficacy and safety in humans. This review highlights the great therapeutic potential of wogonin in terms of CNS protection. However, despite the substantial preclinical evidence, further large-scale clinical studies are necessary. Future researchers need to further explore the long-term efficacy and safety of wogonin in clinical trials and translate it for early application in the clinical treatment of true CNS disorders. |
| format | Article |
| id | doaj-art-3cc0debe74724ec38b56ee9f7fd9e23c |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-3cc0debe74724ec38b56ee9f7fd9e23c2025-02-07T04:46:41ZengElsevierBrain Research Bulletin1873-27472025-02-01221111202Protective effects of wogonin in the treatment of central nervous system and degenerative diseasesQingan Fu0Qingyun Yu1Hongdan Luo2Zhekang Liu3Xiaowei Ma4Huijian Wang5Zhijuan Cheng6Department of Neurology, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1, Minde Road, Nanchang, Jiangxi 330006, China; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, No. 1, Minde Road, Nanchang, Jiangxi 330006, ChinaDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, No. 1, Minde Road, Nanchang, Jiangxi 330006, ChinaDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaRheumatology and Immunology Department, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, ChinaDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, No. 1, Minde Road, Nanchang, Jiangxi 330006, ChinaDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, No. 1, Minde Road, Nanchang, Jiangxi 330006, ChinaDepartment of Neurology, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1, Minde Road, Nanchang, Jiangxi 330006, China; Corresponding author.Wogonin, an O-methylated flavonoid extracted from Scutellaria baicalensis, has demonstrated profound neuroprotective effects in a range of central nervous system (CNS) diseases. This review elucidates the pharmacological mechanisms underlying the protective effects of wogonin in CNS diseases, including ischemic stroke, hemorrhagic stroke, traumatic brain injury, epilepsy, anxiety, neurodegenerative diseases, and CNS infections. Wogonin modulates key signaling pathways, such as the MAPK, NF-κB, and ROS pathways, contributing to its anti-inflammatory, antioxidant, and antiapoptotic properties. In ischemic stroke models, wogonin reduces infarct size and enhances neurological outcomes by mitigating inflammation and oxidative stress. For patients with hemorrhagic stroke and traumatic brain injury, it accelerates hematoma regression, mitigates secondary brain damage, and promotes neurogenesis, making it an entirely new treatment option for patients with limited access to this type of therapy. Its anticonvulsant and anxiolytic effects are mediated through GABA-A receptor modulation. Moreover, wogonin shows promise in treating neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease by promoting autophagy and reducing neuroinflammation. Additionally, it exhibits antiviral properties, offering potential benefits against CNS infections. Despite extensive preclinical evidence, further clinical studies are warranted to confirm its efficacy and safety in humans. This review highlights the great therapeutic potential of wogonin in terms of CNS protection. However, despite the substantial preclinical evidence, further large-scale clinical studies are necessary. Future researchers need to further explore the long-term efficacy and safety of wogonin in clinical trials and translate it for early application in the clinical treatment of true CNS disorders.http://www.sciencedirect.com/science/article/pii/S0361923025000140WogoninCentral nervous systemAnti-inflammatoryAntioxidantNeuroprotectionDegenerative diseases |
| spellingShingle | Qingan Fu Qingyun Yu Hongdan Luo Zhekang Liu Xiaowei Ma Huijian Wang Zhijuan Cheng Protective effects of wogonin in the treatment of central nervous system and degenerative diseases Brain Research Bulletin Wogonin Central nervous system Anti-inflammatory Antioxidant Neuroprotection Degenerative diseases |
| title | Protective effects of wogonin in the treatment of central nervous system and degenerative diseases |
| title_full | Protective effects of wogonin in the treatment of central nervous system and degenerative diseases |
| title_fullStr | Protective effects of wogonin in the treatment of central nervous system and degenerative diseases |
| title_full_unstemmed | Protective effects of wogonin in the treatment of central nervous system and degenerative diseases |
| title_short | Protective effects of wogonin in the treatment of central nervous system and degenerative diseases |
| title_sort | protective effects of wogonin in the treatment of central nervous system and degenerative diseases |
| topic | Wogonin Central nervous system Anti-inflammatory Antioxidant Neuroprotection Degenerative diseases |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025000140 |
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