"MoSpec": A customized and integrated system for model development, verification and validation.
<h4>Background and objective</h4>The growing availability of patient data from several clinical settings, fueled by advanced analysis systems and new diagnostics, presents a unique opportunity. These data can be used to understand disease progression and predict future outcomes. However,...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0316401 |
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| _version_ | 1841555591927955456 |
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| author | Marcello Pompa Simona Panunzi Alessandro Borri Laura D'Orsi Andrea De Gaetano |
| author_facet | Marcello Pompa Simona Panunzi Alessandro Borri Laura D'Orsi Andrea De Gaetano |
| author_sort | Marcello Pompa |
| collection | DOAJ |
| description | <h4>Background and objective</h4>The growing availability of patient data from several clinical settings, fueled by advanced analysis systems and new diagnostics, presents a unique opportunity. These data can be used to understand disease progression and predict future outcomes. However, analysing this vast amount of data requires collaboration between physicians and experts from diverse fields like mathematics and engineering.<h4>Methods</h4>Mathematical models play a crucial role in interpreting patient data and enable in-silico simulations for diagnosis and treatment. To facilitate the creation and sharing of such models, the CNR-IASI BioMatLab group developed the "Gemini" (MoSpec/Autocoder) system, a framework allowing researchers with basic mathematical knowledge to quickly and correctly translate biological problems into Ordinary Differential Equations models. The system facilitates the development and computation of mathematical models for the interpretation of medical and biological phenomena, also using data from the clinical setting or laboratory experiments for parameter estimation.<h4>Results</h4>Gemini automatically generates code in multiple languages (C++, Matlab, R, and Julia) and automatically creates documentation, including code, figures, and visualizations.<h4>Conclusions</h4>This user-friendly approach promotes model sharing and collaboration among researchers, besides vastly increasing group productivity. |
| format | Article |
| id | doaj-art-3cbfab1855334be3953b9f076065b94b |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-3cbfab1855334be3953b9f076065b94b2025-01-08T05:31:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031640110.1371/journal.pone.0316401"MoSpec": A customized and integrated system for model development, verification and validation.Marcello PompaSimona PanunziAlessandro BorriLaura D'OrsiAndrea De Gaetano<h4>Background and objective</h4>The growing availability of patient data from several clinical settings, fueled by advanced analysis systems and new diagnostics, presents a unique opportunity. These data can be used to understand disease progression and predict future outcomes. However, analysing this vast amount of data requires collaboration between physicians and experts from diverse fields like mathematics and engineering.<h4>Methods</h4>Mathematical models play a crucial role in interpreting patient data and enable in-silico simulations for diagnosis and treatment. To facilitate the creation and sharing of such models, the CNR-IASI BioMatLab group developed the "Gemini" (MoSpec/Autocoder) system, a framework allowing researchers with basic mathematical knowledge to quickly and correctly translate biological problems into Ordinary Differential Equations models. The system facilitates the development and computation of mathematical models for the interpretation of medical and biological phenomena, also using data from the clinical setting or laboratory experiments for parameter estimation.<h4>Results</h4>Gemini automatically generates code in multiple languages (C++, Matlab, R, and Julia) and automatically creates documentation, including code, figures, and visualizations.<h4>Conclusions</h4>This user-friendly approach promotes model sharing and collaboration among researchers, besides vastly increasing group productivity.https://doi.org/10.1371/journal.pone.0316401 |
| spellingShingle | Marcello Pompa Simona Panunzi Alessandro Borri Laura D'Orsi Andrea De Gaetano "MoSpec": A customized and integrated system for model development, verification and validation. PLoS ONE |
| title | "MoSpec": A customized and integrated system for model development, verification and validation. |
| title_full | "MoSpec": A customized and integrated system for model development, verification and validation. |
| title_fullStr | "MoSpec": A customized and integrated system for model development, verification and validation. |
| title_full_unstemmed | "MoSpec": A customized and integrated system for model development, verification and validation. |
| title_short | "MoSpec": A customized and integrated system for model development, verification and validation. |
| title_sort | mospec a customized and integrated system for model development verification and validation |
| url | https://doi.org/10.1371/journal.pone.0316401 |
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