Regulatory B cells drive immune evasion in the tumor microenvironment and are involved peritoneal metastasis in gastric cancer

Regulatory B cells drive immune evasion in the tumor microenvironment and are involved peritoneal metastasis in gastric cancer

Abstract Peritoneal metastasis (PM) of gastric cancer (GC) has an immune escape environment. Regulatory B cells (Bregs), characterized by IL-10 production, play an important role in the tumor immunity; however, the function of Bregs in PM remains unclear. We investigated the frequency and effects of...

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Bibliographic Details
Main Authors: Yuta Fujiwara, Jun Kinoshita, Mari Shimada, Hiroto Saito, Toshikatsu Tsuji, Daisuke Yamamoto, Hideki Moriyama, Motoki Horii, Sachiyo Nomura, Takashi Matsushita, Yasuhiko Yamamoto, Noriyuki Inaki
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Regulatory B cell
Gastric cancer
Peritoneal metastasis
PI3K/Akt
Wortmannin
Online Access:https://doi.org/10.1038/s41598-025-11887-x
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