The therapeutic potential of red radish microgreens in modulating inflammation and cancer pathways
This review highlights the therapeutic potential of red radish microgreens (RRMs) as a nutrient-rich food with notable antioxidant, anti-inflammatory, and anticancer properties. Rich in bioactive compounds such as phenolic acids, flavonoids, glucosinolates, isothiocyanates, sulforaphane, and caroten...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | CyTA - Journal of Food |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19476337.2025.2467410 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850138950776127488 |
|---|---|
| author | Trina Ekawai Tallei Nova Hellen Kapantow Nurdjannah Jane Niode Illah Sailah Maghfirah Savitri Muhammad Yamin Lahay Jayanthi Barasarathi |
| author_facet | Trina Ekawai Tallei Nova Hellen Kapantow Nurdjannah Jane Niode Illah Sailah Maghfirah Savitri Muhammad Yamin Lahay Jayanthi Barasarathi |
| author_sort | Trina Ekawai Tallei |
| collection | DOAJ |
| description | This review highlights the therapeutic potential of red radish microgreens (RRMs) as a nutrient-rich food with notable antioxidant, anti-inflammatory, and anticancer properties. Rich in bioactive compounds such as phenolic acids, flavonoids, glucosinolates, isothiocyanates, sulforaphane, and carotenoids, RRMs exhibit the ability to modulate key signaling pathways, including NF-κB, MAPK, JAK/STAT, TGF-β, SRC kinase, COX-2-PGE-2, and Wnt/β-catenin. These pathways regulate critical processes such as cell proliferation, angiogenesis, migration, and apoptosis, offering potential for inflammation and cancer mitigation. The review also explores the suitability of RRMs as space food, emphasizing their rapid growth, minimal resource requirements, and ability to support astronauts’ health by addressing oxidative stress, immune dysregulation, and inflammation in microgravity. While current evidence underscores their health-promoting effects, further in vitro and in vivo studies are essential to elucidate their molecular mechanisms and optimize their applications in medicine and space nutrition. |
| format | Article |
| id | doaj-art-3cbbda5f43ba49d597b5fc97161c1b64 |
| institution | OA Journals |
| issn | 1947-6337 1947-6345 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | CyTA - Journal of Food |
| spelling | doaj-art-3cbbda5f43ba49d597b5fc97161c1b642025-08-20T02:30:28ZengTaylor & Francis GroupCyTA - Journal of Food1947-63371947-63452025-12-0123110.1080/19476337.2025.2467410The therapeutic potential of red radish microgreens in modulating inflammation and cancer pathwaysTrina Ekawai Tallei0Nova Hellen Kapantow1Nurdjannah Jane Niode2Illah Sailah3Maghfirah Savitri4Muhammad Yamin Lahay5Jayanthi Barasarathi6Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, North Sulawesi, IndonesiaDepartment of Nutrition, Faculty of Medicine, Sam Ratulangi University, Manado, IndonesiaDepartment of Dermatology and Venereology, Faculty of Medicine, Sam Ratulangi University, Manado, IndonesiaAgroindustrial Engineering Study Program, Department of Agroindustrial Technology, Faculty of Agricultural Engineering and Technology, IPB University, Bogor, IndonesiaFaculty of Medicine, Sam Ratulangi University, Manado, North Sulawesi, IndonesiaHarvest Gorontalo Indonesia, Pilohayanga Village, Telaga District, Gorontalo Regency, Gorontalo, IndonesiaFaculty of Health and Life Sciences, INTI International University, Persiaran Perdana BBN, Putra, Nilai, MalaysiaThis review highlights the therapeutic potential of red radish microgreens (RRMs) as a nutrient-rich food with notable antioxidant, anti-inflammatory, and anticancer properties. Rich in bioactive compounds such as phenolic acids, flavonoids, glucosinolates, isothiocyanates, sulforaphane, and carotenoids, RRMs exhibit the ability to modulate key signaling pathways, including NF-κB, MAPK, JAK/STAT, TGF-β, SRC kinase, COX-2-PGE-2, and Wnt/β-catenin. These pathways regulate critical processes such as cell proliferation, angiogenesis, migration, and apoptosis, offering potential for inflammation and cancer mitigation. The review also explores the suitability of RRMs as space food, emphasizing their rapid growth, minimal resource requirements, and ability to support astronauts’ health by addressing oxidative stress, immune dysregulation, and inflammation in microgravity. While current evidence underscores their health-promoting effects, further in vitro and in vivo studies are essential to elucidate their molecular mechanisms and optimize their applications in medicine and space nutrition.https://www.tandfonline.com/doi/10.1080/19476337.2025.2467410Red radish microgreensbioactive compoundsanti-inflammatoryanticancersignaling pathway |
| spellingShingle | Trina Ekawai Tallei Nova Hellen Kapantow Nurdjannah Jane Niode Illah Sailah Maghfirah Savitri Muhammad Yamin Lahay Jayanthi Barasarathi The therapeutic potential of red radish microgreens in modulating inflammation and cancer pathways CyTA - Journal of Food Red radish microgreens bioactive compounds anti-inflammatory anticancer signaling pathway |
| title | The therapeutic potential of red radish microgreens in modulating inflammation and cancer pathways |
| title_full | The therapeutic potential of red radish microgreens in modulating inflammation and cancer pathways |
| title_fullStr | The therapeutic potential of red radish microgreens in modulating inflammation and cancer pathways |
| title_full_unstemmed | The therapeutic potential of red radish microgreens in modulating inflammation and cancer pathways |
| title_short | The therapeutic potential of red radish microgreens in modulating inflammation and cancer pathways |
| title_sort | therapeutic potential of red radish microgreens in modulating inflammation and cancer pathways |
| topic | Red radish microgreens bioactive compounds anti-inflammatory anticancer signaling pathway |
| url | https://www.tandfonline.com/doi/10.1080/19476337.2025.2467410 |
| work_keys_str_mv | AT trinaekawaitallei thetherapeuticpotentialofredradishmicrogreensinmodulatinginflammationandcancerpathways AT novahellenkapantow thetherapeuticpotentialofredradishmicrogreensinmodulatinginflammationandcancerpathways AT nurdjannahjaneniode thetherapeuticpotentialofredradishmicrogreensinmodulatinginflammationandcancerpathways AT illahsailah thetherapeuticpotentialofredradishmicrogreensinmodulatinginflammationandcancerpathways AT maghfirahsavitri thetherapeuticpotentialofredradishmicrogreensinmodulatinginflammationandcancerpathways AT muhammadyaminlahay thetherapeuticpotentialofredradishmicrogreensinmodulatinginflammationandcancerpathways AT jayanthibarasarathi thetherapeuticpotentialofredradishmicrogreensinmodulatinginflammationandcancerpathways AT trinaekawaitallei therapeuticpotentialofredradishmicrogreensinmodulatinginflammationandcancerpathways AT novahellenkapantow therapeuticpotentialofredradishmicrogreensinmodulatinginflammationandcancerpathways AT nurdjannahjaneniode therapeuticpotentialofredradishmicrogreensinmodulatinginflammationandcancerpathways AT illahsailah therapeuticpotentialofredradishmicrogreensinmodulatinginflammationandcancerpathways AT maghfirahsavitri therapeuticpotentialofredradishmicrogreensinmodulatinginflammationandcancerpathways AT muhammadyaminlahay therapeuticpotentialofredradishmicrogreensinmodulatinginflammationandcancerpathways AT jayanthibarasarathi therapeuticpotentialofredradishmicrogreensinmodulatinginflammationandcancerpathways |