The Eucommia ulmoides - Achyranthes bidentata pair and their active monomers exert synergistic therapeutic potential for osteoarthritis through the PI3K-AKT pathway

The Eucommia ulmoides - Achyranthes bidentata pair and their active monomers exert synergistic therapeutic potential for osteoarthritis through the PI3K-AKT pathway

BackgroundOsteoarthritis is characterized by articular cartilage degradation, involving inflammation-mediated chondrocyte apoptosis and extracellular matrix destruction. Eucommia ulmoides and Achyranthes bidentata constitute a classic herbal pair for OA treatment, yet their combinatorial effects and...

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Main Authors: Chun Chen, Lei Lv, Yueying Huang, Fangyuan Xie, Mingzhu Gao, Sailiang Zeng, Zijun Wang, Xue Jiang, Yangyang Zhan, Leilei Bao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
drug pair
osteoarthritis
synergies
Pi3k-akt
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1571884/full
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