Is the acid load of the diet related to esophageal cancer? A case-control study
Summary: Background: Esophageal adenocarcinoma (EAC) is a prevalent type of cancer both globallyand in the northern regions of Iran. The relationship between dietary acid load (DAL) and EAC is not well established. Therefore, a study was conducted to investigate the association between DAL and EAC....
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Clinical Nutrition Open Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667268525000385 |
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| author | Omid Nikpayam Parmis Mirzaei Golbon Sohrab Amirmahdi Najafi Reza Eghdam Zamiri Alireza Ostadrahimi |
| author_facet | Omid Nikpayam Parmis Mirzaei Golbon Sohrab Amirmahdi Najafi Reza Eghdam Zamiri Alireza Ostadrahimi |
| author_sort | Omid Nikpayam |
| collection | DOAJ |
| description | Summary: Background: Esophageal adenocarcinoma (EAC) is a prevalent type of cancer both globallyand in the northern regions of Iran. The relationship between dietary acid load (DAL) and EAC is not well established. Therefore, a study was conducted to investigate the association between DAL and EAC. Methods: This case-control study involved 120 individuals with EAC as the case group and 240 individuals without a history of malignancy as the control group. Dietary intake was assessed using a valid food frequency questionnaire (FFQ), and the dietary acid load (DAL) was calculated using a valid formula. The association between DAL and EAC was evaluated using multivariate logistic regression analysis. Results: The results of the current study indicate that, after adjusting for potential confounding factors, individuals with a higher potential renal acid load (PRAL) score in their diet have an elevated risk of developing EAC (OR: 2.3; 95%CI: 4.41–1.11; p:0.03). In contrast, there was no significant association between the net endogenous acid production (NEAP) index score and the risk of EAC (OR: 1.76; 95%CI: 0.9–3.24; p: 0.07). Conclusion: The findings of the current study show that DAL has a direct and significant relationship with the risk of EAC. |
| format | Article |
| id | doaj-art-3cb620cbf8c943e4853b01b3ee89192f |
| institution | DOAJ |
| issn | 2667-2685 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Nutrition Open Science |
| spelling | doaj-art-3cb620cbf8c943e4853b01b3ee89192f2025-08-20T03:19:53ZengElsevierClinical Nutrition Open Science2667-26852025-06-016119019910.1016/j.nutos.2025.03.011Is the acid load of the diet related to esophageal cancer? A case-control studyOmid Nikpayam0Parmis Mirzaei1Golbon Sohrab2Amirmahdi Najafi3Reza Eghdam Zamiri4Alireza Ostadrahimi5Department of Nutrition, School of Health, Golestan University of Medical Sciences, Gorgan, Iran; Corresponding author. School of Health, Golestan University of Medical Sciences, Gorgan, Iran.Clinical Nutrition and Dietetics Department, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, IranClinical Nutrition and Dietetics Department, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, IranQazvin Blood Transfusion Organization, Qzvin, IranDepartment of Radiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, IranNutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Corresponding author. School of Nutrition and Food Sciences, Attar-Neishaburi St., Golgasht Alley, Azadi Blvd., Tabriz, Iran.Summary: Background: Esophageal adenocarcinoma (EAC) is a prevalent type of cancer both globallyand in the northern regions of Iran. The relationship between dietary acid load (DAL) and EAC is not well established. Therefore, a study was conducted to investigate the association between DAL and EAC. Methods: This case-control study involved 120 individuals with EAC as the case group and 240 individuals without a history of malignancy as the control group. Dietary intake was assessed using a valid food frequency questionnaire (FFQ), and the dietary acid load (DAL) was calculated using a valid formula. The association between DAL and EAC was evaluated using multivariate logistic regression analysis. Results: The results of the current study indicate that, after adjusting for potential confounding factors, individuals with a higher potential renal acid load (PRAL) score in their diet have an elevated risk of developing EAC (OR: 2.3; 95%CI: 4.41–1.11; p:0.03). In contrast, there was no significant association between the net endogenous acid production (NEAP) index score and the risk of EAC (OR: 1.76; 95%CI: 0.9–3.24; p: 0.07). Conclusion: The findings of the current study show that DAL has a direct and significant relationship with the risk of EAC.http://www.sciencedirect.com/science/article/pii/S2667268525000385NEAPPRALEsophagealCancerCase-control |
| spellingShingle | Omid Nikpayam Parmis Mirzaei Golbon Sohrab Amirmahdi Najafi Reza Eghdam Zamiri Alireza Ostadrahimi Is the acid load of the diet related to esophageal cancer? A case-control study Clinical Nutrition Open Science NEAP PRAL Esophageal Cancer Case-control |
| title | Is the acid load of the diet related to esophageal cancer? A case-control study |
| title_full | Is the acid load of the diet related to esophageal cancer? A case-control study |
| title_fullStr | Is the acid load of the diet related to esophageal cancer? A case-control study |
| title_full_unstemmed | Is the acid load of the diet related to esophageal cancer? A case-control study |
| title_short | Is the acid load of the diet related to esophageal cancer? A case-control study |
| title_sort | is the acid load of the diet related to esophageal cancer a case control study |
| topic | NEAP PRAL Esophageal Cancer Case-control |
| url | http://www.sciencedirect.com/science/article/pii/S2667268525000385 |
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