Is the acid load of the diet related to esophageal cancer? A case-control study
Summary: Background: Esophageal adenocarcinoma (EAC) is a prevalent type of cancer both globallyand in the northern regions of Iran. The relationship between dietary acid load (DAL) and EAC is not well established. Therefore, a study was conducted to investigate the association between DAL and EAC....
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | Clinical Nutrition Open Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667268525000385 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Summary: Background: Esophageal adenocarcinoma (EAC) is a prevalent type of cancer both globallyand in the northern regions of Iran. The relationship between dietary acid load (DAL) and EAC is not well established. Therefore, a study was conducted to investigate the association between DAL and EAC. Methods: This case-control study involved 120 individuals with EAC as the case group and 240 individuals without a history of malignancy as the control group. Dietary intake was assessed using a valid food frequency questionnaire (FFQ), and the dietary acid load (DAL) was calculated using a valid formula. The association between DAL and EAC was evaluated using multivariate logistic regression analysis. Results: The results of the current study indicate that, after adjusting for potential confounding factors, individuals with a higher potential renal acid load (PRAL) score in their diet have an elevated risk of developing EAC (OR: 2.3; 95%CI: 4.41–1.11; p:0.03). In contrast, there was no significant association between the net endogenous acid production (NEAP) index score and the risk of EAC (OR: 1.76; 95%CI: 0.9–3.24; p: 0.07). Conclusion: The findings of the current study show that DAL has a direct and significant relationship with the risk of EAC. |
|---|---|
| ISSN: | 2667-2685 |