Tumor-associated macrophages promote bladder cancer metastasis through the CCL20-CCR6 axis

Tumor-associated macrophages promote bladder cancer metastasis through the CCL20-CCR6 axis

We investigated the mechanisms of interaction between bladder cancer (BC) cells and tumor-associated macrophages (TAMs). Coculturing BC cell lines (UMUC3 and T24) with macrophage-like cells differentiated from THP-1 into M2-like TAMs revealed a decrease in Cluster of Differentiation (CD) 68 expressi...

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Main Authors: Ryunosuke Nakagawa, Kouji Izumi, Kaoru Hiratsuka, Takahiro Inaba, Yoshiki Koketsu, Ren Toriumi, Shuhei Aoyama, Taiki Kamijima, Hiroshi Kano, Tomoyuki Makino, Renato Naito, Suguru Kadomoto, Hiroaki Iwamoto, Hiroshi Yaegashi, Shohei Kawaguchi, Takahiro Nohara, Kazuyoshi Shigehara, Hiroki Nakata, Wen-Jye Lin, Atsushi Mizokami
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Bladder cancer
Tumor assosociated Macrophage
CCL20
CCR6
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558624001441
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