Gastrointestinal health and serum proteins are associated with BMD in postmenopausal women: a cross-sectional study
Abstract Background With increasing age, the social and economic burdens of postmenopausal osteoporosis are steadily increasing. This study aimed to investigate the factors that influence the development of postmenopausal osteoporosis. Methods Postmenopausal women at the Affiliated Hospital of Jiang...
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BMC
2024-11-01
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| Series: | Nutrition & Metabolism |
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| Online Access: | https://doi.org/10.1186/s12986-024-00865-1 |
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| author | Han Wang Qiuxia Jiang Jiai Yan Ju Yang Jing Sun Yingyu Wang Gege Huang Feng Zhang Hong Cao Xuesong Wang Dan Li |
| author_facet | Han Wang Qiuxia Jiang Jiai Yan Ju Yang Jing Sun Yingyu Wang Gege Huang Feng Zhang Hong Cao Xuesong Wang Dan Li |
| author_sort | Han Wang |
| collection | DOAJ |
| description | Abstract Background With increasing age, the social and economic burdens of postmenopausal osteoporosis are steadily increasing. This study aimed to investigate the factors that influence the development of postmenopausal osteoporosis. Methods Postmenopausal women at the Affiliated Hospital of Jiangnan University from January 2023 to December 2023 were recruited for BMD examination. The patients were divided into a normal group, an osteopenia group and an osteoporosis group according to their T value. Questionnaires, including the Gastrointestinal Symptom Rating Scale and Short Form 12, were administered through face-to-face interviews. Bone turnover markers and serum protein levels of Fasting venous blood were detected. Results A total of 222 postmenopausal women met the inclusion criteria were recruited. Univariate analysis revealed statistically significant differences in age, education, BMI, supplementation with soy products, supplementation with dairy products, supplementation with other nutritional supplements, exercise frequency, gastrointestinal symptom score, quality of life, 25(OH)D, total protein, albumin and prealbumin among the three groups (P < 0.05). Pearson correlation analysis revealed that gastrointestinal symptoms (r = -0.518, P < 0.01) was negatively correlated with BMD in postmenopausal women, while PCS (r = 0.194, P = 0.004), MCS (r = 0.305, P < 0.01), 25(OH)D (r = 0.531, P < 0.01), total protein (r = 0.324, P < 0.01), albumin (r = 0.341, P < 0.01) and prealbumin (r = 0.259, P < 0.01) were positively correlated with BMD. Logistic regression analysis revealed that both the gastrointestinal symptom score and serum 25(OH)D level were found to have a significant association with BMD (both P < 0.01). This association remained significant even after adjusting for age, BMI, education level, dietary habits, and exercise frequency. Conclusion Gastrointestinal symptoms and serum 25(OH)D elevel are associated with increased risk of osteoporosis in postmenopausal women and may be useful in predicting osteoporosis in postmenopausal women. |
| format | Article |
| id | doaj-art-3cb4fc84b87f49aeb257df1485ac7430 |
| institution | DOAJ |
| issn | 1743-7075 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
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| series | Nutrition & Metabolism |
| spelling | doaj-art-3cb4fc84b87f49aeb257df1485ac74302025-08-20T02:49:56ZengBMCNutrition & Metabolism1743-70752024-11-0121111110.1186/s12986-024-00865-1Gastrointestinal health and serum proteins are associated with BMD in postmenopausal women: a cross-sectional studyHan Wang0Qiuxia Jiang1Jiai Yan2Ju Yang3Jing Sun4Yingyu Wang5Gege Huang6Feng Zhang7Hong Cao8Xuesong Wang9Dan Li10Department of Nutrition, Affiliated Hospital of Jiangnan UniversityDepartment of Nutrition, Affiliated Hospital of Jiangnan UniversityDepartment of Nutrition, Affiliated Hospital of Jiangnan UniversityDepartment of Nutrition, Affiliated Hospital of Jiangnan UniversityDepartment of Nutrition, Affiliated Hospital of Jiangnan UniversityDepartment of Nutrition, Affiliated Hospital of Jiangnan UniversityInstitute of Future Food Technology, JITRIDepartment of Nutrition, Affiliated Hospital of Jiangnan UniversityDepartment of Nutrition, Affiliated Hospital of Jiangnan UniversityDepartment of Nutrition, Affiliated Hospital of Jiangnan UniversityDepartment of Nutrition, Affiliated Hospital of Jiangnan UniversityAbstract Background With increasing age, the social and economic burdens of postmenopausal osteoporosis are steadily increasing. This study aimed to investigate the factors that influence the development of postmenopausal osteoporosis. Methods Postmenopausal women at the Affiliated Hospital of Jiangnan University from January 2023 to December 2023 were recruited for BMD examination. The patients were divided into a normal group, an osteopenia group and an osteoporosis group according to their T value. Questionnaires, including the Gastrointestinal Symptom Rating Scale and Short Form 12, were administered through face-to-face interviews. Bone turnover markers and serum protein levels of Fasting venous blood were detected. Results A total of 222 postmenopausal women met the inclusion criteria were recruited. Univariate analysis revealed statistically significant differences in age, education, BMI, supplementation with soy products, supplementation with dairy products, supplementation with other nutritional supplements, exercise frequency, gastrointestinal symptom score, quality of life, 25(OH)D, total protein, albumin and prealbumin among the three groups (P < 0.05). Pearson correlation analysis revealed that gastrointestinal symptoms (r = -0.518, P < 0.01) was negatively correlated with BMD in postmenopausal women, while PCS (r = 0.194, P = 0.004), MCS (r = 0.305, P < 0.01), 25(OH)D (r = 0.531, P < 0.01), total protein (r = 0.324, P < 0.01), albumin (r = 0.341, P < 0.01) and prealbumin (r = 0.259, P < 0.01) were positively correlated with BMD. Logistic regression analysis revealed that both the gastrointestinal symptom score and serum 25(OH)D level were found to have a significant association with BMD (both P < 0.01). This association remained significant even after adjusting for age, BMI, education level, dietary habits, and exercise frequency. Conclusion Gastrointestinal symptoms and serum 25(OH)D elevel are associated with increased risk of osteoporosis in postmenopausal women and may be useful in predicting osteoporosis in postmenopausal women.https://doi.org/10.1186/s12986-024-00865-1Postmenopausal osteoporosisOsteopeniaGastrointestinal symptomsSerum proteinBone turnover markersBone mass density |
| spellingShingle | Han Wang Qiuxia Jiang Jiai Yan Ju Yang Jing Sun Yingyu Wang Gege Huang Feng Zhang Hong Cao Xuesong Wang Dan Li Gastrointestinal health and serum proteins are associated with BMD in postmenopausal women: a cross-sectional study Nutrition & Metabolism Postmenopausal osteoporosis Osteopenia Gastrointestinal symptoms Serum protein Bone turnover markers Bone mass density |
| title | Gastrointestinal health and serum proteins are associated with BMD in postmenopausal women: a cross-sectional study |
| title_full | Gastrointestinal health and serum proteins are associated with BMD in postmenopausal women: a cross-sectional study |
| title_fullStr | Gastrointestinal health and serum proteins are associated with BMD in postmenopausal women: a cross-sectional study |
| title_full_unstemmed | Gastrointestinal health and serum proteins are associated with BMD in postmenopausal women: a cross-sectional study |
| title_short | Gastrointestinal health and serum proteins are associated with BMD in postmenopausal women: a cross-sectional study |
| title_sort | gastrointestinal health and serum proteins are associated with bmd in postmenopausal women a cross sectional study |
| topic | Postmenopausal osteoporosis Osteopenia Gastrointestinal symptoms Serum protein Bone turnover markers Bone mass density |
| url | https://doi.org/10.1186/s12986-024-00865-1 |
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