Effect of pemafibrate in reducing intestinal long-chain fatty acid absorption and hepatic fibrosis in metabolic dysfunction-associated steatohepatitis rats

Effect of pemafibrate in reducing intestinal long-chain fatty acid absorption and hepatic fibrosis in metabolic dysfunction-associated steatohepatitis rats

Abstract Background Pemafibrate helps regulate fatty acid dynamics in the liver, potentially preventing metabolic dysfunction-associated steatohepatitis (MASH). However, its effect on intestinal long-chain fatty acid (LCFA) metabolism in MASH remains unclear. Thus, we aimed to examine the influence...

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Bibliographic Details
Main Authors: Masaya Okada, Masakazu Hanayama, Yasunori Yamamoto, Teruki Miyake, Osamu Yoshida, Eiji Takeshita, Yoshio Ikeda, Yoichi Hiasa
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Gastroenterology
Subjects:
CD36
Microsomal triglyceride transfer protein
Triglycerides
Lipotoxicity
Peroxisomes
Pemafibrate
Online Access:https://doi.org/10.1186/s12876-025-03967-z
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