Brain natriuretic peptide is a biomarker of atrial fibrillation in hemodialysis patients
Objectives Atrial fibrillation (AF) is the most common persistent arrhythmia and has adverse outcomes in hemodialysis patients. It is obscure the relationship between BNP and AF in hemodialysis patients. This study investigated the interventionable predictors of AF in hemodialysis patients.Methods I...
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Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2463563 |
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| author | Ling Yu Jia Huang Yanchun Li Han Li |
| author_facet | Ling Yu Jia Huang Yanchun Li Han Li |
| author_sort | Ling Yu |
| collection | DOAJ |
| description | Objectives Atrial fibrillation (AF) is the most common persistent arrhythmia and has adverse outcomes in hemodialysis patients. It is obscure the relationship between BNP and AF in hemodialysis patients. This study investigated the interventionable predictors of AF in hemodialysis patients.Methods In this retrospectively observational cohort study, a total of 205 hemodialysis patients were screened and 140 were enrolled. The anthropometrics, laboratory parameters, electrocardiogram and echocardiogram were collected. The patients were divided into three groups based on the tertiles of BNP value. Kaplan–Meier curves were used to compare the incidence of AF among different BNP groups. Restricted cubic spline curves and receiver operator characteristic curves were drawn, and Cox proportional hazards models were applied to identify the predictive value of BNP and the other related factors for incident AF.Results During the 5-year follow-up period, 33 (23.6%) individuals developed incident AF. The incidence of AF increased significantly with an increase in the BNP. Cox proportional hazards models indicated that age, dialysis vintage, left atrial diameter, ultrafiltration rate, hs-CRP and BNP were independent risk factors for incident AF. The hazard ratios of BNP (per 100 pg/mL) were 1.038 (95% confidence interval, 1.012–1.064, p = 0.004). BNP had a predictive value for the occurrence of AF (area under the curve = 0.734).Conclusions BNP was a good predictor of incident AF in hemodialysis patients. Higher BNP had an increasing adverse event rate of AF. Further research should be needed to clarify the best reference range of BNP in hemodialysis patients. |
| format | Article |
| id | doaj-art-3ca879b54e074bf9a20876fa0681a45f |
| institution | DOAJ |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-3ca879b54e074bf9a20876fa0681a45f2025-08-20T03:12:54ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2025.2463563Brain natriuretic peptide is a biomarker of atrial fibrillation in hemodialysis patientsLing Yu0Jia Huang1Yanchun Li2Han Li3Department of Nephrology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Nephrology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Nephrology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Nephrology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaObjectives Atrial fibrillation (AF) is the most common persistent arrhythmia and has adverse outcomes in hemodialysis patients. It is obscure the relationship between BNP and AF in hemodialysis patients. This study investigated the interventionable predictors of AF in hemodialysis patients.Methods In this retrospectively observational cohort study, a total of 205 hemodialysis patients were screened and 140 were enrolled. The anthropometrics, laboratory parameters, electrocardiogram and echocardiogram were collected. The patients were divided into three groups based on the tertiles of BNP value. Kaplan–Meier curves were used to compare the incidence of AF among different BNP groups. Restricted cubic spline curves and receiver operator characteristic curves were drawn, and Cox proportional hazards models were applied to identify the predictive value of BNP and the other related factors for incident AF.Results During the 5-year follow-up period, 33 (23.6%) individuals developed incident AF. The incidence of AF increased significantly with an increase in the BNP. Cox proportional hazards models indicated that age, dialysis vintage, left atrial diameter, ultrafiltration rate, hs-CRP and BNP were independent risk factors for incident AF. The hazard ratios of BNP (per 100 pg/mL) were 1.038 (95% confidence interval, 1.012–1.064, p = 0.004). BNP had a predictive value for the occurrence of AF (area under the curve = 0.734).Conclusions BNP was a good predictor of incident AF in hemodialysis patients. Higher BNP had an increasing adverse event rate of AF. Further research should be needed to clarify the best reference range of BNP in hemodialysis patients.https://www.tandfonline.com/doi/10.1080/0886022X.2025.2463563Atrial fibrillationhemodialysisbrain natriuretic peptideultrafiltration ratepredictor |
| spellingShingle | Ling Yu Jia Huang Yanchun Li Han Li Brain natriuretic peptide is a biomarker of atrial fibrillation in hemodialysis patients Renal Failure Atrial fibrillation hemodialysis brain natriuretic peptide ultrafiltration rate predictor |
| title | Brain natriuretic peptide is a biomarker of atrial fibrillation in hemodialysis patients |
| title_full | Brain natriuretic peptide is a biomarker of atrial fibrillation in hemodialysis patients |
| title_fullStr | Brain natriuretic peptide is a biomarker of atrial fibrillation in hemodialysis patients |
| title_full_unstemmed | Brain natriuretic peptide is a biomarker of atrial fibrillation in hemodialysis patients |
| title_short | Brain natriuretic peptide is a biomarker of atrial fibrillation in hemodialysis patients |
| title_sort | brain natriuretic peptide is a biomarker of atrial fibrillation in hemodialysis patients |
| topic | Atrial fibrillation hemodialysis brain natriuretic peptide ultrafiltration rate predictor |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2463563 |
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