Role of urinary trace elements in diabetic kidney disease: a cross-sectional analysis
Introduction The balance of trace elements plays an important role in diabetic kidney disease (DKD) patients. However, studies on the differences in urinary trace elements across different DKD stages are scarce. This study aimed to explore the associations between nine essential trace elements and D...
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BMJ Publishing Group
2024-12-01
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| Series: | BMJ Open Diabetes Research & Care |
| Online Access: | https://drc.bmj.com/content/12/6/e004454.full |
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| author | Jing Zhou Yuchen Zhang Fengmin Shao Lijuan Guo Yue Gu Tianrui Gao Jia Lv Lizhen Lu Weitian Tang Shiwei Zhu Ruiqi Jia Chang Gao |
| author_facet | Jing Zhou Yuchen Zhang Fengmin Shao Lijuan Guo Yue Gu Tianrui Gao Jia Lv Lizhen Lu Weitian Tang Shiwei Zhu Ruiqi Jia Chang Gao |
| author_sort | Jing Zhou |
| collection | DOAJ |
| description | Introduction The balance of trace elements plays an important role in diabetic kidney disease (DKD) patients. However, studies on the differences in urinary trace elements across different DKD stages are scarce. This study aimed to explore the associations between nine essential trace elements and DKD.Research design and methods This cross-sectional analysis included 830 diabetic patients. Participants were classified into non-DKD (NDKD) and DKD, the latter was further grouped into mid and end DKD based on estimated glomerular filtration rate (eGFR), and the case and control were matched based on age and sex. The concentration of urinary trace elements was measured with inductively coupled plasma mass spectrometry.Results Urinary concentrations of copper (Cu) and manganese (Mn) in DKD patients were significantly higher than that of NDKD patients, whereas that of iron (Fe), cobalt, selenium, and nickel (Ni) of DKD were lower. Positive correlations between urinary Mn/Cu and the risk of mid-stage and end-stage DKD were revealed by conditional logistic regression, while Fe and Ni were negatively associated with the risk of DKD. In mixed effect analyses, no significant trend was found for joint trace element exposure and risk of mid DKD, while negative associations between combined effects of trace elements and the risk of end DKD were observed.Conclusions This study revealed different associations between trace elements and the risk of mid and end DKD using both single and mixture effect modeling. The results suggested that the urinary trace element profile might be associated with the progression of DKD, which provides important insights for understanding the pathogenesis of DKD and developing individualized nutritive management strategies. |
| format | Article |
| id | doaj-art-3ca777a1b5aa41b787f247fc602682ee |
| institution | OA Journals |
| issn | 2052-4897 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Diabetes Research & Care |
| spelling | doaj-art-3ca777a1b5aa41b787f247fc602682ee2025-08-20T02:34:52ZengBMJ Publishing GroupBMJ Open Diabetes Research & Care2052-48972024-12-0112610.1136/bmjdrc-2024-004454Role of urinary trace elements in diabetic kidney disease: a cross-sectional analysisJing Zhou0Yuchen Zhang1Fengmin Shao2Lijuan Guo3Yue Gu4Tianrui Gao5Jia Lv6Lizhen Lu7Weitian Tang8Shiwei Zhu9Ruiqi Jia10Chang Gao11Department of Cardiology, Peking University First Hospital, Beijing, China1Anhui Medical University, China27 Department of Nephrology, The People’s Hospital of Zhengzhou University and Henan Provincial People’s Hospital, Zhengzhou, ChinaAnesthesiology, West China Hospital of Sichuan University, Chengdu, ChinaAnhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Nephrology, Henan Provincial People`s Hospital, Zhengzhou, Henan, ChinaDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, Anhui, ChinaIntroduction The balance of trace elements plays an important role in diabetic kidney disease (DKD) patients. However, studies on the differences in urinary trace elements across different DKD stages are scarce. This study aimed to explore the associations between nine essential trace elements and DKD.Research design and methods This cross-sectional analysis included 830 diabetic patients. Participants were classified into non-DKD (NDKD) and DKD, the latter was further grouped into mid and end DKD based on estimated glomerular filtration rate (eGFR), and the case and control were matched based on age and sex. The concentration of urinary trace elements was measured with inductively coupled plasma mass spectrometry.Results Urinary concentrations of copper (Cu) and manganese (Mn) in DKD patients were significantly higher than that of NDKD patients, whereas that of iron (Fe), cobalt, selenium, and nickel (Ni) of DKD were lower. Positive correlations between urinary Mn/Cu and the risk of mid-stage and end-stage DKD were revealed by conditional logistic regression, while Fe and Ni were negatively associated with the risk of DKD. In mixed effect analyses, no significant trend was found for joint trace element exposure and risk of mid DKD, while negative associations between combined effects of trace elements and the risk of end DKD were observed.Conclusions This study revealed different associations between trace elements and the risk of mid and end DKD using both single and mixture effect modeling. The results suggested that the urinary trace element profile might be associated with the progression of DKD, which provides important insights for understanding the pathogenesis of DKD and developing individualized nutritive management strategies.https://drc.bmj.com/content/12/6/e004454.full |
| spellingShingle | Jing Zhou Yuchen Zhang Fengmin Shao Lijuan Guo Yue Gu Tianrui Gao Jia Lv Lizhen Lu Weitian Tang Shiwei Zhu Ruiqi Jia Chang Gao Role of urinary trace elements in diabetic kidney disease: a cross-sectional analysis BMJ Open Diabetes Research & Care |
| title | Role of urinary trace elements in diabetic kidney disease: a cross-sectional analysis |
| title_full | Role of urinary trace elements in diabetic kidney disease: a cross-sectional analysis |
| title_fullStr | Role of urinary trace elements in diabetic kidney disease: a cross-sectional analysis |
| title_full_unstemmed | Role of urinary trace elements in diabetic kidney disease: a cross-sectional analysis |
| title_short | Role of urinary trace elements in diabetic kidney disease: a cross-sectional analysis |
| title_sort | role of urinary trace elements in diabetic kidney disease a cross sectional analysis |
| url | https://drc.bmj.com/content/12/6/e004454.full |
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