In vitro and ex vivo evaluation of preclinical models for FAP-targeted theranostics: differences and relevance for radiotracer evaluation

In vitro and ex vivo evaluation of preclinical models for FAP-targeted theranostics: differences and relevance for radiotracer evaluation

Abstract Background Fibroblast activation protein (FAP) is an attractive target for cancer theranostics. Although FAP-targeted nuclear imaging demonstrated promising clinical results, only sub-optimal results are reported for targeted radionuclide therapy (TRT). Preclinical research is crucial in se...

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Bibliographic Details
Main Authors: Circe D. van der Heide, Joana D. Campeiro, Eline A. M. Ruigrok, Lilian van den Brink, Shashikanth Ponnala, Shawn M. Hillier, Simone U. Dalm
Format: Article
Language:English
Published: SpringerOpen 2024-12-01
Series:EJNMMI Research
Subjects:
Cancer-associated fibroblast (CAF)
Fibroblast activation protein (FAP)
Targeted radionuclide therapy (TRT)
Radionuclide theranostics
Preclinical models
Online Access:https://doi.org/10.1186/s13550-024-01191-6
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