DALIA- a comprehensive resource of Disease Alleles in Arab population.
The Arab population encompasses over 420 million people characterized by genetic admixture and a consequent rich genetic diversity. A number of genetic diseases have been reported for the first time from the population. Additionally a high prevalence of some genetic diseases including autosomal rece...
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| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0244567&type=printable |
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| author | Aastha Vatsyayan Parul Sharma Shrey Gupta Sumiti Sandhu Seetha Lakshmi Venu Vandana Sharma Bouabid Badaoui Kaidi Azedine Serti Youssef Anna Rajab Alaaeldin Fayez Seema Madinur Anop Ranawat Kavita Pandhare Srinivasan Ramachandran Sridhar Sivasubbu Vinod Scaria |
| author_facet | Aastha Vatsyayan Parul Sharma Shrey Gupta Sumiti Sandhu Seetha Lakshmi Venu Vandana Sharma Bouabid Badaoui Kaidi Azedine Serti Youssef Anna Rajab Alaaeldin Fayez Seema Madinur Anop Ranawat Kavita Pandhare Srinivasan Ramachandran Sridhar Sivasubbu Vinod Scaria |
| author_sort | Aastha Vatsyayan |
| collection | DOAJ |
| description | The Arab population encompasses over 420 million people characterized by genetic admixture and a consequent rich genetic diversity. A number of genetic diseases have been reported for the first time from the population. Additionally a high prevalence of some genetic diseases including autosomal recessive disorders such as hemoglobinopathies and familial mediterranean fever have been found in the population and across the region. There is a paucity of databases cataloguing genetic variants of clinical relevance from the population. The availability of such a catalog could have implications in precise diagnosis, genetic epidemiology and prevention of disease. To fill in the gap, we have compiled DALIA, a comprehensive compendium of genetic variants reported in literature and implicated in genetic diseases reported from the Arab population. The database aims to act as an effective resource for population-scale and sub-population specific variant analyses, enabling a ready reference aiding clinical interpretation of genetic variants, genetic epidemiology, as well as facilitating rapid screening and a quick reference for evaluating evidence on genetic diseases. |
| format | Article |
| id | doaj-art-3c9468c283d04cd4bde9c81b2a995be1 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-3c9468c283d04cd4bde9c81b2a995be12025-08-20T02:11:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01161e024456710.1371/journal.pone.0244567DALIA- a comprehensive resource of Disease Alleles in Arab population.Aastha VatsyayanParul SharmaShrey GuptaSumiti SandhuSeetha Lakshmi VenuVandana SharmaBouabid BadaouiKaidi AzedineSerti YoussefAnna RajabAlaaeldin FayezSeema MadinurAnop RanawatKavita PandhareSrinivasan RamachandranSridhar SivasubbuVinod ScariaThe Arab population encompasses over 420 million people characterized by genetic admixture and a consequent rich genetic diversity. A number of genetic diseases have been reported for the first time from the population. Additionally a high prevalence of some genetic diseases including autosomal recessive disorders such as hemoglobinopathies and familial mediterranean fever have been found in the population and across the region. There is a paucity of databases cataloguing genetic variants of clinical relevance from the population. The availability of such a catalog could have implications in precise diagnosis, genetic epidemiology and prevention of disease. To fill in the gap, we have compiled DALIA, a comprehensive compendium of genetic variants reported in literature and implicated in genetic diseases reported from the Arab population. The database aims to act as an effective resource for population-scale and sub-population specific variant analyses, enabling a ready reference aiding clinical interpretation of genetic variants, genetic epidemiology, as well as facilitating rapid screening and a quick reference for evaluating evidence on genetic diseases.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0244567&type=printable |
| spellingShingle | Aastha Vatsyayan Parul Sharma Shrey Gupta Sumiti Sandhu Seetha Lakshmi Venu Vandana Sharma Bouabid Badaoui Kaidi Azedine Serti Youssef Anna Rajab Alaaeldin Fayez Seema Madinur Anop Ranawat Kavita Pandhare Srinivasan Ramachandran Sridhar Sivasubbu Vinod Scaria DALIA- a comprehensive resource of Disease Alleles in Arab population. PLoS ONE |
| title | DALIA- a comprehensive resource of Disease Alleles in Arab population. |
| title_full | DALIA- a comprehensive resource of Disease Alleles in Arab population. |
| title_fullStr | DALIA- a comprehensive resource of Disease Alleles in Arab population. |
| title_full_unstemmed | DALIA- a comprehensive resource of Disease Alleles in Arab population. |
| title_short | DALIA- a comprehensive resource of Disease Alleles in Arab population. |
| title_sort | dalia a comprehensive resource of disease alleles in arab population |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0244567&type=printable |
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