Inhibitory Effect of Ferulic Acid and Isoferulic Acid on the Production of Macrophage Inflammatory Protein-2 in Response to Respiratory Syncytial Virus Infection in RAW264.7 Cells
We investigated the effect of ferulic acid (FA) and isoferulic acid (IFA), which are the main active components of the rhizoma of Cimicifuga heracleifolia (CH), an anti-inflammatory drug used frequently in Japanese traditional medicine, on the production of macrophage inflammatory protein-2 (MIR-2)...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1999-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629359990513 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850105298103042048 |
|---|---|
| author | S. Sakai H. Kawamata T. Kogure N. Mantani K. Terasawa M. Umatake H. Ochiai |
| author_facet | S. Sakai H. Kawamata T. Kogure N. Mantani K. Terasawa M. Umatake H. Ochiai |
| author_sort | S. Sakai |
| collection | DOAJ |
| description | We investigated the effect of ferulic acid (FA) and isoferulic acid (IFA), which are the main active components of the rhizoma of Cimicifuga heracleifolia (CH), an anti-inflammatory drug used frequently in Japanese traditional medicine, on the production of macrophage inflammatory protein-2 (MIR-2) in a murine macrophage cell line, RAW264.7, in response to respiratory syncytial virus (RSV) infection. Following the exposure of cells to RSV for 20 h, the MIP-2 level in condition medium was increased to about 20 ng/ml, although this level in mock-infected cells was negligible. In the presence of either FA or IFA, RSV-infected cells reduced MIP-2 production in a dose-dependent manner. These data suggest that FA and IFA might be responsible, at least in part, for the anti-inflammatory drug effect of CH extract through the inhibition of MIP-2 production. |
| format | Article |
| id | doaj-art-3c89a2ce92eb4b92b754dc0df2dd76bf |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1999-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3c89a2ce92eb4b92b754dc0df2dd76bf2025-08-20T02:39:08ZengWileyMediators of Inflammation0962-93511466-18611999-01-018317317510.1080/09629359990513Inhibitory Effect of Ferulic Acid and Isoferulic Acid on the Production of Macrophage Inflammatory Protein-2 in Response to Respiratory Syncytial Virus Infection in RAW264.7 CellsS. Sakai0H. Kawamata1T. Kogure2N. Mantani3K. Terasawa4M. Umatake5H. Ochiai6Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930– 0194, JapanDepartment of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930– 0194, JapanDepartment of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930– 0194, JapanDepartment of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930– 0194, JapanDepartment of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930– 0194, JapanDepartment of Human Sciences, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930– 0194, JapanDepartment of Human Sciences, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930– 0194, JapanWe investigated the effect of ferulic acid (FA) and isoferulic acid (IFA), which are the main active components of the rhizoma of Cimicifuga heracleifolia (CH), an anti-inflammatory drug used frequently in Japanese traditional medicine, on the production of macrophage inflammatory protein-2 (MIR-2) in a murine macrophage cell line, RAW264.7, in response to respiratory syncytial virus (RSV) infection. Following the exposure of cells to RSV for 20 h, the MIP-2 level in condition medium was increased to about 20 ng/ml, although this level in mock-infected cells was negligible. In the presence of either FA or IFA, RSV-infected cells reduced MIP-2 production in a dose-dependent manner. These data suggest that FA and IFA might be responsible, at least in part, for the anti-inflammatory drug effect of CH extract through the inhibition of MIP-2 production.http://dx.doi.org/10.1080/09629359990513 |
| spellingShingle | S. Sakai H. Kawamata T. Kogure N. Mantani K. Terasawa M. Umatake H. Ochiai Inhibitory Effect of Ferulic Acid and Isoferulic Acid on the Production of Macrophage Inflammatory Protein-2 in Response to Respiratory Syncytial Virus Infection in RAW264.7 Cells Mediators of Inflammation |
| title | Inhibitory Effect of Ferulic Acid and Isoferulic Acid on the Production of Macrophage
Inflammatory Protein-2 in Response to Respiratory Syncytial Virus Infection in RAW264.7 Cells |
| title_full | Inhibitory Effect of Ferulic Acid and Isoferulic Acid on the Production of Macrophage
Inflammatory Protein-2 in Response to Respiratory Syncytial Virus Infection in RAW264.7 Cells |
| title_fullStr | Inhibitory Effect of Ferulic Acid and Isoferulic Acid on the Production of Macrophage
Inflammatory Protein-2 in Response to Respiratory Syncytial Virus Infection in RAW264.7 Cells |
| title_full_unstemmed | Inhibitory Effect of Ferulic Acid and Isoferulic Acid on the Production of Macrophage
Inflammatory Protein-2 in Response to Respiratory Syncytial Virus Infection in RAW264.7 Cells |
| title_short | Inhibitory Effect of Ferulic Acid and Isoferulic Acid on the Production of Macrophage
Inflammatory Protein-2 in Response to Respiratory Syncytial Virus Infection in RAW264.7 Cells |
| title_sort | inhibitory effect of ferulic acid and isoferulic acid on the production of macrophage inflammatory protein 2 in response to respiratory syncytial virus infection in raw264 7 cells |
| url | http://dx.doi.org/10.1080/09629359990513 |
| work_keys_str_mv | AT ssakai inhibitoryeffectofferulicacidandisoferulicacidontheproductionofmacrophageinflammatoryprotein2inresponsetorespiratorysyncytialvirusinfectioninraw2647cells AT hkawamata inhibitoryeffectofferulicacidandisoferulicacidontheproductionofmacrophageinflammatoryprotein2inresponsetorespiratorysyncytialvirusinfectioninraw2647cells AT tkogure inhibitoryeffectofferulicacidandisoferulicacidontheproductionofmacrophageinflammatoryprotein2inresponsetorespiratorysyncytialvirusinfectioninraw2647cells AT nmantani inhibitoryeffectofferulicacidandisoferulicacidontheproductionofmacrophageinflammatoryprotein2inresponsetorespiratorysyncytialvirusinfectioninraw2647cells AT kterasawa inhibitoryeffectofferulicacidandisoferulicacidontheproductionofmacrophageinflammatoryprotein2inresponsetorespiratorysyncytialvirusinfectioninraw2647cells AT mumatake inhibitoryeffectofferulicacidandisoferulicacidontheproductionofmacrophageinflammatoryprotein2inresponsetorespiratorysyncytialvirusinfectioninraw2647cells AT hochiai inhibitoryeffectofferulicacidandisoferulicacidontheproductionofmacrophageinflammatoryprotein2inresponsetorespiratorysyncytialvirusinfectioninraw2647cells |