Large Language Models and Their Applications in Drug Discovery and Development: A Primer
ABSTRACT Large language models (LLMs) have emerged as powerful tools in many fields, including clinical pharmacology and translational medicine. This paper aims to provide a comprehensive primer on the applications of LLMs to these disciplines. We will explore the fundamental concepts of LLMs, their...
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | Clinical and Translational Science |
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| Online Access: | https://doi.org/10.1111/cts.70205 |
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| author | James Lu Keunwoo Choi Maksim Eremeev Jogarao Gobburu Srijib Goswami Qi Liu Gary Mo Cynthia J. Musante Mohamed H. Shahin |
| author_facet | James Lu Keunwoo Choi Maksim Eremeev Jogarao Gobburu Srijib Goswami Qi Liu Gary Mo Cynthia J. Musante Mohamed H. Shahin |
| author_sort | James Lu |
| collection | DOAJ |
| description | ABSTRACT Large language models (LLMs) have emerged as powerful tools in many fields, including clinical pharmacology and translational medicine. This paper aims to provide a comprehensive primer on the applications of LLMs to these disciplines. We will explore the fundamental concepts of LLMs, their potential applications in drug discovery and development processes ranging from facilitating target identification to aiding preclinical research and clinical trial analysis, and practical use cases such as assisting with medical writing and accelerating analytical workflows in quantitative clinical pharmacology. By the end of this paper, clinical pharmacologists and translational scientists will have a clearer understanding of how to leverage LLMs to enhance their research and development efforts. |
| format | Article |
| id | doaj-art-3c83fe9de74b46bfb505192fdfb31c26 |
| institution | OA Journals |
| issn | 1752-8054 1752-8062 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Science |
| spelling | doaj-art-3c83fe9de74b46bfb505192fdfb31c262025-08-20T02:18:43ZengWileyClinical and Translational Science1752-80541752-80622025-04-01184n/an/a10.1111/cts.70205Large Language Models and Their Applications in Drug Discovery and Development: A PrimerJames Lu0Keunwoo Choi1Maksim Eremeev2Jogarao Gobburu3Srijib Goswami4Qi Liu5Gary Mo6Cynthia J. Musante7Mohamed H. Shahin8Clinical Pharmacology Genentech Inc. South San Francisco California USAPrescient Design Genentech Inc. South San Francisco California USAPrescient Design Genentech Inc. South San Francisco California USAUniversity of Maryland School of Pharmacy Baltimore Maryland USAInsightRX Inc. San Francisco California USAOffice of Clinical Pharmacology Center for Drug Evaluation and Research, U.S. FDA Silver Springs Maryland USAPfizer Research & Development Currently at Eli Lilly and Company Indianapolis Indiana USAPfizer Research & Development Cambridge Massachusetts USAPfizer Research & Development Groton Connecticut USAABSTRACT Large language models (LLMs) have emerged as powerful tools in many fields, including clinical pharmacology and translational medicine. This paper aims to provide a comprehensive primer on the applications of LLMs to these disciplines. We will explore the fundamental concepts of LLMs, their potential applications in drug discovery and development processes ranging from facilitating target identification to aiding preclinical research and clinical trial analysis, and practical use cases such as assisting with medical writing and accelerating analytical workflows in quantitative clinical pharmacology. By the end of this paper, clinical pharmacologists and translational scientists will have a clearer understanding of how to leverage LLMs to enhance their research and development efforts.https://doi.org/10.1111/cts.70205artificial intelligenceclinical pharmacologydrug developmentdrug discoverylarge language modeltranslational science |
| spellingShingle | James Lu Keunwoo Choi Maksim Eremeev Jogarao Gobburu Srijib Goswami Qi Liu Gary Mo Cynthia J. Musante Mohamed H. Shahin Large Language Models and Their Applications in Drug Discovery and Development: A Primer Clinical and Translational Science artificial intelligence clinical pharmacology drug development drug discovery large language model translational science |
| title | Large Language Models and Their Applications in Drug Discovery and Development: A Primer |
| title_full | Large Language Models and Their Applications in Drug Discovery and Development: A Primer |
| title_fullStr | Large Language Models and Their Applications in Drug Discovery and Development: A Primer |
| title_full_unstemmed | Large Language Models and Their Applications in Drug Discovery and Development: A Primer |
| title_short | Large Language Models and Their Applications in Drug Discovery and Development: A Primer |
| title_sort | large language models and their applications in drug discovery and development a primer |
| topic | artificial intelligence clinical pharmacology drug development drug discovery large language model translational science |
| url | https://doi.org/10.1111/cts.70205 |
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