Interactions between ABC gene polymorphisms and processing speed in predicting depression severity
Abstract Background ABC family genes encode ATP-binding cassette proteins, which are involved in the transport of various substances and are associated with major depressive disorder (MDD); however, their clinical significance in MDD remains unclear. Therefore, this study aimed to investigate whethe...
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BMC
2025-02-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-025-06507-x |
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| author | Meijiang Jin Lei Ji Maojia Ran Yan Bi Hang Zhang Yuanmei Tao Hanmei Xu Shoukang Zou Hong Zhang Tao Yu Li Yin |
| author_facet | Meijiang Jin Lei Ji Maojia Ran Yan Bi Hang Zhang Yuanmei Tao Hanmei Xu Shoukang Zou Hong Zhang Tao Yu Li Yin |
| author_sort | Meijiang Jin |
| collection | DOAJ |
| description | Abstract Background ABC family genes encode ATP-binding cassette proteins, which are involved in the transport of various substances and are associated with major depressive disorder (MDD); however, their clinical significance in MDD remains unclear. Therefore, this study aimed to investigate whether ABC family genes are associated with cognitive function, and the combined effects of genes and cognitive function on the severity of depression. Method Linear models or logistic regression models were used to investigate the associations of ABC family gene variants with clinical symptoms and cognitive function in 805 MDD patients (12–65 years old) and 1493 age-matched healthy controls (HCs). Seven single nucleotide polymorphisms (rs28401781, rs4148739, rs3747802, rs1109866, rs1109867, rs3731885, and rs3755047) of ABCB1 and ABCB6 were selected. The cognitive function was assessed by the Wisconsin Card Sorting Test (WCST), Tower of Hanoi Test (TOH), Trail Making Test (TMT), and Verbal Fluency Test (VF). Results Significant differences in gene frequency and genotype frequency were observed at the rs1109866 (X 2 = 8.22, p = 0.004; X 2 = 9.82, p = 0.007) and rs1109867 (X 2 = 7.35, p = 0.007; X 2 = 9.15, p = 0.010) between MDD patients and HCs, even after correction. While rs28401781 (t = 2.78, p = 0.006) and rs4148739 (t = 3.08, p = 0.003) were associated with the TOH test. And both rs1109866 and rs1109867 interacted with TMT results to influence depression severity in MDD patients. Conclusion The results suggest that ABC family genes influence the severity of depression through cognitive functioning, providing possible evidence for genetic markers in MDD patients. |
| format | Article |
| id | doaj-art-3c7ac67940744b5280d1d36f3efa4df2 |
| institution | Kabale University |
| issn | 1471-244X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj-art-3c7ac67940744b5280d1d36f3efa4df22025-02-09T12:49:23ZengBMCBMC Psychiatry1471-244X2025-02-012511910.1186/s12888-025-06507-xInteractions between ABC gene polymorphisms and processing speed in predicting depression severityMeijiang Jin0Lei Ji1Maojia Ran2Yan Bi3Hang Zhang4Yuanmei Tao5Hanmei Xu6Shoukang Zou7Hong Zhang8Tao Yu9Li Yin10Psychological Center, West China Hospital, Sichuan UniversityBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong UniversityPsychological Center, West China Hospital, Sichuan UniversityBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong UniversityPsychological Center, West China Hospital, Sichuan UniversityPsychological Center, West China Hospital, Sichuan UniversityPsychological Center, West China Hospital, Sichuan UniversityPsychological Center, West China Hospital, Sichuan UniversityPsychological Center, West China Hospital, Sichuan UniversityBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong UniversityPsychological Center, West China Hospital, Sichuan UniversityAbstract Background ABC family genes encode ATP-binding cassette proteins, which are involved in the transport of various substances and are associated with major depressive disorder (MDD); however, their clinical significance in MDD remains unclear. Therefore, this study aimed to investigate whether ABC family genes are associated with cognitive function, and the combined effects of genes and cognitive function on the severity of depression. Method Linear models or logistic regression models were used to investigate the associations of ABC family gene variants with clinical symptoms and cognitive function in 805 MDD patients (12–65 years old) and 1493 age-matched healthy controls (HCs). Seven single nucleotide polymorphisms (rs28401781, rs4148739, rs3747802, rs1109866, rs1109867, rs3731885, and rs3755047) of ABCB1 and ABCB6 were selected. The cognitive function was assessed by the Wisconsin Card Sorting Test (WCST), Tower of Hanoi Test (TOH), Trail Making Test (TMT), and Verbal Fluency Test (VF). Results Significant differences in gene frequency and genotype frequency were observed at the rs1109866 (X 2 = 8.22, p = 0.004; X 2 = 9.82, p = 0.007) and rs1109867 (X 2 = 7.35, p = 0.007; X 2 = 9.15, p = 0.010) between MDD patients and HCs, even after correction. While rs28401781 (t = 2.78, p = 0.006) and rs4148739 (t = 3.08, p = 0.003) were associated with the TOH test. And both rs1109866 and rs1109867 interacted with TMT results to influence depression severity in MDD patients. Conclusion The results suggest that ABC family genes influence the severity of depression through cognitive functioning, providing possible evidence for genetic markers in MDD patients.https://doi.org/10.1186/s12888-025-06507-xMajor depressive disorder (MDD)SeverityGeneticCognitiveProcessing speed |
| spellingShingle | Meijiang Jin Lei Ji Maojia Ran Yan Bi Hang Zhang Yuanmei Tao Hanmei Xu Shoukang Zou Hong Zhang Tao Yu Li Yin Interactions between ABC gene polymorphisms and processing speed in predicting depression severity BMC Psychiatry Major depressive disorder (MDD) Severity Genetic Cognitive Processing speed |
| title | Interactions between ABC gene polymorphisms and processing speed in predicting depression severity |
| title_full | Interactions between ABC gene polymorphisms and processing speed in predicting depression severity |
| title_fullStr | Interactions between ABC gene polymorphisms and processing speed in predicting depression severity |
| title_full_unstemmed | Interactions between ABC gene polymorphisms and processing speed in predicting depression severity |
| title_short | Interactions between ABC gene polymorphisms and processing speed in predicting depression severity |
| title_sort | interactions between abc gene polymorphisms and processing speed in predicting depression severity |
| topic | Major depressive disorder (MDD) Severity Genetic Cognitive Processing speed |
| url | https://doi.org/10.1186/s12888-025-06507-x |
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